Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/117794
Type: Theses
Title: The Mucosal Barrier in Chronic Rhinosinusitis
Author: Murphy, Jae Viktor
Issue Date: 2018
School/Discipline: Adelaide Medical School
Abstract: Chronic rhinosinusitis (CRS) is a heterogeneous disease characterised by inflammation of the nose and paranasal sinuses, which results in nasal obstruction, rhinorrhoea, post-nasal drip, facial pressure, and alterations in smell. The pathophysiology of CRS is complex and involved interactions between the host, microbial flora, and environment. Studies have shown that the mucosa of CRS sufferers demonstrates signs of defective barrier function, although little is known about the contributing factors to this process. Understanding epithelial barrier dysfunction in the gastrointestinal, skin, and pulmonary systems highlights the various contributing factors to this process, which may be paralleled in the paranasal sinuses. It appears that bacterial mediated mechanism, inflammatory surroundings, and the divalent metal zinc are important in these systems. Staphylococcus aureus has been implicated in the pathogenesis and persistence of CRS, poorer wound healing, and increased disease severity. Additionally, it is known that S. aureus secretes an unknown factor that perturbs the airway barrier in-vitro. Previous research has suggested that zinc concentrations may be lower in CRS, particularly in patients with nasal polyposis, however little is known about the consequences of localised zinc deficiency in CRS. This thesis examines the S. aureus secretome to elucidate the factor or factors involved in barrier disruption. Furthermore, the role of zinc in mucosal barrier integrity and CRS has been delineated.
Advisor: Wormald, Peter-John
Psaltis, Alkiviadis
Vreugde, Sarah
Dissertation Note: Thesis (Ph.D.) -- University of Adelaide, Adelaide Medical School, 2018
Keywords: Chronic rhinosinusitis
tight junction
barrier
Staphylococcus aureus
zinc
Provenance: This thesis is currently under Embargo and not available.
Appears in Collections:Research Theses

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