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Type: Journal article
Title: Use of different combination diphtheria-tetanus-acellular pertussis vaccines does not increase risk of 30-day infant mortality. A population-based linkage cohort study using administrative data from the Australian Childhood Immunisation Register and the National Death Index
Author: Duszynski, K.
Pratt, N.
Lynch, J.
Berry, J.
Gold, M.
Citation: Vaccine, 2019; 37(2):280-288
Publisher: Elsevier
Issue Date: 2019
ISSN: 0264-410X
Statement of
Katherine M. Duszynski, Nicole L. Pratt, John W. Lynch, Jesia G. Berry, Michael S. Gold, on behalf of the Vaccine Assessment Using Linked Data(VALiD) Working Group
Abstract: Objective: To determine whether differences in combination DTaP vaccine types at 2, 4 and 6 months of age were associated with mortality (all-cause or non-specific), within 30 days of vaccination. Design: Observational nationwide cohort study. Setting: Linked population data from the Australian Childhood Immunisation Register and National Death Index. Participants: Australian infants administered a combination trivalent, quadrivalent or hexavalent DTaP vaccine (DTaP types) between January 1999 and December 2010 at 2, 4 and 6 months as part of the primary vaccination series. The study population included 2.9, 2.6, & 2.3 million children in the 2, 4 and 6 month vaccine cohorts, respectively. Main Outcome Measures: Infants were evaluated for the primary outcome of all-cause mortality within 30 days. A secondary outcome was non-specific mortality (unknown cause of death) within 30 days of vaccination. Non-specific mortality was defined as underlying or other cause of death codes, R95 'Sudden infant death syndrome', R96 'Other sudden death, cause unknown', R98 'Unattended death', R99 'Other ill-defined and unspecified cause of mortality' or where no cause of death was recorded. Results: The rate of 30 day all-cause mortality was low and declined from 127.4 to 59.3 deaths per 100,000 person-years between 2 and 6 month cohorts. When compared with trivalent DTaP vaccines, no elevated risk in all-cause or non-specific mortality was seen with any quadrivalent or hexavalent DTaP vaccines, for any cohort. Conclusion: Use of routine DTaP combination vaccines with differing disease antigens administered during the first six months of life is not associated with infant mortality.
Keywords: Vaccine Assessment Using Linked Data (VALiD) Working Group
Rights: © 2018 Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.vaccine.2018.11.025
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