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https://hdl.handle.net/2440/117924
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dc.contributor.author | Duszynski, K.M. | - |
dc.contributor.author | Pratt, N.L. | - |
dc.contributor.author | Lynch, J.W. | - |
dc.contributor.author | Berry, J.G. | - |
dc.contributor.author | Gold, M.S. | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Vaccine, 2019; 37(2):280-288 | - |
dc.identifier.issn | 0264-410X | - |
dc.identifier.issn | 1873-2518 | - |
dc.identifier.uri | http://hdl.handle.net/2440/117924 | - |
dc.description.abstract | Objective: To determine whether differences in combination DTaP vaccine types at 2, 4 and 6 months of age were associated with mortality (all-cause or non-specific), within 30 days of vaccination. Design: Observational nationwide cohort study. Setting: Linked population data from the Australian Childhood Immunisation Register and National Death Index. Participants: Australian infants administered a combination trivalent, quadrivalent or hexavalent DTaP vaccine (DTaP types) between January 1999 and December 2010 at 2, 4 and 6 months as part of the primary vaccination series. The study population included 2.9, 2.6, & 2.3 million children in the 2, 4 and 6 month vaccine cohorts, respectively. Main Outcome Measures: Infants were evaluated for the primary outcome of all-cause mortality within 30 days. A secondary outcome was non-specific mortality (unknown cause of death) within 30 days of vaccination. Non-specific mortality was defined as underlying or other cause of death codes, R95 'Sudden infant death syndrome', R96 'Other sudden death, cause unknown', R98 'Unattended death', R99 'Other ill-defined and unspecified cause of mortality' or where no cause of death was recorded. Results: The rate of 30 day all-cause mortality was low and declined from 127.4 to 59.3 deaths per 100,000 person-years between 2 and 6 month cohorts. When compared with trivalent DTaP vaccines, no elevated risk in all-cause or non-specific mortality was seen with any quadrivalent or hexavalent DTaP vaccines, for any cohort. Conclusion: Use of routine DTaP combination vaccines with differing disease antigens administered during the first six months of life is not associated with infant mortality. | - |
dc.description.statementofresponsibility | Katherine M. Duszynski, Nicole L. Pratt, John W. Lynch, Jesia G. Berry, Michael S. Gold, on behalf of the Vaccine Assessment Using Linked Data(VALiD) Working Group | - |
dc.language.iso | en | - |
dc.publisher | Elsevier | - |
dc.rights | © 2018 Elsevier Ltd. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.vaccine.2018.11.025 | - |
dc.subject | Vaccine Assessment Using Linked Data (VALiD) Working Group | - |
dc.title | Use of different combination diphtheria-tetanus-acellular pertussis vaccines does not increase risk of 30-day infant mortality. A population-based linkage cohort study using administrative data from the Australian Childhood Immunisation Register and the National Death Index | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.vaccine.2018.11.025 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/LP0882394 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Pratt, N.L. [0000-0001-8730-8910] | - |
dc.identifier.orcid | Lynch, J.W. [0000-0003-2781-7902] | - |
dc.identifier.orcid | Berry, J.G. [0000-0002-4446-7927] | - |
dc.identifier.orcid | Gold, M.S. [0000-0003-1312-5331] | - |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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