Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/117946
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dc.contributor.authorMorton, J.en
dc.contributor.authorBao, S.en
dc.contributor.authorVanags, L.en
dc.contributor.authorTsatralis, T.en
dc.contributor.authorRidiandries, A.en
dc.contributor.authorSiu, C.en
dc.contributor.authorNg, K.en
dc.contributor.authorTan, J.en
dc.contributor.authorCelermajer, D.en
dc.contributor.authorNg, M.en
dc.contributor.authorBursill, C.en
dc.date.issued2018en
dc.identifier.citationJACC: Basic to Translational Science, 2018; 3(2):187-199en
dc.identifier.issn2452-302Xen
dc.identifier.issn2452-302Xen
dc.identifier.urihttp://hdl.handle.net/2440/117946-
dc.description.abstractPreclinical studies have shown benefit of apolipoprotein A-I (apoA-I)/high-density lipoprotein (HDL) raising in atherosclerosis; however, this has not yet translated into a successful clinical therapy. Our studies demonstrate that apoA-I raising is more effective at reducing early-stage atherosclerosis than late-stage disease, indicating that the timing of HDL raising is a critical factor in its atheroprotective effects. To date, HDL-raising clinical trials have only been performed in aged patients with advanced atherosclerotic disease. Our findings therefore provide insight, related to important temporal aspects of HDL raising, as to why the clinical trials have thus far been largely neutral.en
dc.description.statementofresponsibilityJamie Morton, Shisan Bao, Laura Z. Vanags, Tania Tsatralis, Anisyah Ridiandries, Chung-Wah Siu, Kwong-Man Ng, Joanne T.M. Tan, David S. Celermajer, Martin K.C. Ng, Christina A. Bursillen
dc.language.isoenen
dc.publisherElsevieren
dc.rights© 2018 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.en
dc.subjectAtherosclerosis, cholesterol; high-density lipoproteinsen
dc.titleStrikingly different atheroprotective effects of apolipoprotein A-I in early- versus late-stage atherosclerosisen
dc.typeJournal articleen
dc.identifier.rmid0030086605en
dc.identifier.doi10.1016/j.jacbts.2017.11.004en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/598402en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/632512en
dc.identifier.pubid419081-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS14en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidTan, J. [0000-0003-1875-4882]en
dc.identifier.orcidBursill, C. [0000-0002-0682-8760]en
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