Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/117947
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Type: Journal article
Title: Streptococcus pneumoniae: transmission, colonization and invasion
Author: Weiser, J.
Ferreira, D.
Paton, J.
Citation: Nature Reviews Microbiology, 2018; 16(6):355-367
Publisher: Springer Nature
Issue Date: 2018
ISSN: 1740-1526
1740-1534
Statement of
Responsibility: 
Jeffrey N. Weiser, Daniela M. Ferreira and James C. Paton
Abstract: Streptococcus pneumoniae has a complex relationship with its obligate human host. On the one hand, the pneumococci are highly adapted commensals, and their main reservoir on the mucosal surface of the upper airways of carriers enables transmission. On the other hand, they can cause severe disease when bacterial and host factors allow them to invade essentially sterile sites, such as the middle ear spaces, lungs, bloodstream and meninges. Transmission, colonization and invasion depend on the remarkable ability of S. pneumoniae to evade or take advantage of the host inflammatory and immune responses. The different stages of pneumococcal carriage and disease have been investigated in detail in animal models and, more recently, in experimental human infection. Furthermore, widespread vaccination and the resulting immune pressure have shed light on pneumococcal population dynamics and pathogenesis. Here, we review the mechanistic insights provided by these studies on the multiple and varied interactions of the pneumococcus and its host.
Keywords: Nasopharynx
Humans
Streptococcus pneumoniae
Pneumococcal Infections
Carrier State
Bacterial Adhesion
Rights: © 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
DOI: 10.1038/s41579-018-0001-8
Grant ID: http://purl.org/au-research/grants/nhmrc/1071659
Appears in Collections:Aurora harvest 8
Molecular and Biomedical Science publications

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