Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/118038
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Type: Journal article
Title: Changes of left ventricular mechanics after trans-catheter aortic valve implantation and surgical aortic valve replacement for severe aortic stenosis: a tissue-tracking cardiac magnetic resonance study
Author: Nucifora, G.
Tantiongco, J.
Crouch, G.
Bennetts, J.
Sinhal, A.
Tully, P.
Bradbrook, C.
Baker, R.
Selvanayagam, J.
Citation: International Journal of Cardiology, 2017; 228:184-190
Publisher: Elsevier
Issue Date: 2017
ISSN: 0167-5273
1874-1754
Statement of
Responsibility: 
Gaetano Nucifora, John-Paul Tantiongco, Gareth Crouch, Jayme Bennetts, Ajay Sinhal, Phillip J. Tully, Craig Bradbrook, Robert A. Baker, Joseph B. Selvanayagam
Abstract: Background: Left ventricular (LV) mechanics are impaired in patients with severe aortic stenosis (AS). The aim of the present study was to assess their changes early and late after trans-catheter aortic valve implantation (TAVI) and surgical aortic valve replacement (AVR) using cardiac magnetic resonance (CMR) tissue-tracking imaging. Methods: In 59 patients with severe AS undergoing either TAVI (n=35) or surgical AVR (n=24), CMR with late gadolinium enhancement (LGE) imaging was performed before and early post-procedure to evaluate LV function and mass, and presence/extent of LGE. A third CMR scan was performed in 29 patients after a mean follow-up of 15±4months. Tissue-tracking analysis was applied to cine CMR images, to assess LV global longitudinal (GLS), circumferential (GCS) and radial (GRS) strains. Results: The TAVI and surgical AVR groups were similar with respect to baseline (p=0.14) and early post-procedure (p=0.16) LV ejection fraction. However, baseline LV GLS was significantly impaired in TAVI patients compared to surgical AVR patients (p=0.025). Early post-procedure, TAVI resulted in a significant improvement of LV GLS (p=0.003), while a significant worsening of LV GLS was observed early after surgical AVR (p=0.012). At longer term follow-up, both TAVI and surgical AVR groups experienced a significant reduction of LV mass and a significant improvement of LV myocardial mechanics in all the three directions. Conclusions: Treatment-specific differences in the changes of LV myocardial mechanics early after afterload release by TAVI and surgical AVR are present. Later, both interventions are associated with an improvement of LV myocardial deformation, alongside a regression of LV hypertrophy.
Keywords: Aortic stenosis; cardiac magnetic resonance; fibrosis; hypertrophy; myocardial mechanics; tissue-tracking
Rights: © 2016 Elsevier Ireland Ltd. All rights reserved.
RMID: 0030058843
DOI: 10.1016/j.ijcard.2016.11.200
Appears in Collections:Medicine publications

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