Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/118074
Type: Thesis
Title: Inter-individual variability in platelet adenylate and soluble guanylate cyclase signaling: therapeutic perspectives
Author: Imam, Md Hasan
Issue Date: 2018
School/Discipline: Adelaide Medical School
Abstract: Variability in integrity of platelet prostanoid adenylate cyclase signaling: pathogenetic and therapeutic implication The prostanoid-adenylate cyclase (PG/AC) signaling system plays a major role in inhibiting platelet aggregation and resultant thrombosis. In the studies carried out in this thesis, it was shown that: - (a) Integrity of PG/AC signaling exerts a major influence of individual responses to inhibitors of the P2Y12 receptor. (b) Patients with threatened myocardial infarction have impairment of PG/AC signaling relative to normals. (c) Coronary artery spasms (CAS) is associated with impairment of both PG/AC and nitric oxide signaling, which may be pivotal to occurrence of CAS. (d) PG/AC signaling is potentiated by the anti-anginal agent perhexiline.
Advisor: Horowitz, John
Chirkov, Yuliy
Dissertation Note: Thesis (Ph.D.) -- University of Adelaide, Adelaide Medical School, 2018
Provenance: This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exceptions. If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legals
Appears in Collections:Research Theses

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