Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/118174
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dc.contributor.authorHeruc, G.en
dc.contributor.authorLittle, T.en
dc.contributor.authorKohn, M.en
dc.contributor.authorMadden, S.en
dc.contributor.authorClarke, S.en
dc.contributor.authorHorowitz, M.en
dc.contributor.authorFeinle-Bisset, C.en
dc.date.issued2019en
dc.identifier.citationNutrients, 2019; 11(1):59-1-59-16en
dc.identifier.issn2072-6643en
dc.identifier.issn2072-6643en
dc.identifier.urihttp://hdl.handle.net/2440/118174-
dc.description.abstractFactors underlying disturbed appetite perception in anorexia nervosa (AN) are poorly characterized. We examined in patients with AN whether fasting and postprandial appetite perceptions, gastrointestinal (GI) hormones, GI symptoms and state anxiety (i) differed from healthy controls (HCs) and (ii) were modified by two weeks of refeeding. 22 female adolescent inpatients with restricting AN, studied on hospital admission once medically stable (Wk0), and after one (Wk1) and two (Wk2) weeks of high-calorie refeeding, were compared with 17 age-matched HCs. After a 4 h fast, appetite perceptions, GI symptoms, state anxiety, and plasma acyl-ghrelin, cholecystokinin (CCK), peptide tyrosine tyrosine (PYY) and pancreatic polypeptide (PP) concentrations were assessed at baseline and in response to a mixed-nutrient test-meal (479 kcal). Compared with HCs, in patients with AN at Wk0, baseline ghrelin, PYY, fullness, bloating and anxiety were higher, and hunger less, and in response to the meal, ghrelin, bloating and anxiety were greater, and hunger less (all p < 0.05). After two weeks of refeeding, there was no change in baseline or postprandial ghrelin or bloating, or postprandial anxiety, but baseline PYY, fullness and anxiety decreased, and baseline and postprandial hunger increased (p < 0.05). We conclude that in AN, refeeding for 2 weeks was associated with improvements in PYY, appetite and baseline anxiety, while increased ghrelin, bloating and postprandial anxiety persisted.en
dc.description.statementofresponsibilityGabriella A. Heruc, Tanya J. Little, Michael Kohn, Sloane Madden, Simon Clarke, Michael Horowitz and Christine Feinle-Bisseten
dc.language.isoenen
dc.publisherMDPIen
dc.rights© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en
dc.subjectbloating; cholecystokinin; fullness; gastrointestinal hormones; hunger; malnutrition; nutritional rehabilitation; pancreatic polypeptide; starvation; stressen
dc.titleAppetite perceptions, gastrointestinal symptoms, ghrelin, peptide YY and state anxiety are disturbed in adolescent females with anorexia nervosa and only partially restored with short-term refeedingen
dc.typeJournal articleen
dc.identifier.rmid0030106565en
dc.identifier.doi10.3390/nu11010059en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1022706en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/627002en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1103020en
dc.identifier.pubid455094-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS10en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidHeruc, G. [0000-0002-6257-6828]en
dc.identifier.orcidLittle, T. [0000-0001-9814-1036]en
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]en
dc.identifier.orcidFeinle-Bisset, C. [0000-0001-6848-0125]en
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