Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/118175
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Type: Journal article
Title: Latent psychotic symptom profiles amongst people who use methamphetamine: what do they tell us about existing diagnostic categories?
Author: Ali, R.
Mcketin, R.
Citation: Frontiers in Psychiatry, 2018; 9:1-8
Publisher: Frontiers Media
Issue Date: 2018
ISSN: 1664-0640
1664-0640
Statement of
Responsibility: 
Rebecca McKetin, Alexandra Voce, Richard Burns, Robert Ali, Dan I. Lubman, Amanda L. Baker and David J. Castle
Abstract: The inability to distinguish clearly between methamphetamine-related psychosis and schizophrenia has led to the suggestion that “methamphetamine psychosis” does not represent a distinct diagnostic entity but rather that the drug has triggered a vulnerability to schizophrenia. We tested this possibility by exploring the latent class structure of psychotic symptoms amongst people who use the drug and examining how these latent symptom profiles correspond to a diagnosis of schizophrenia. Latent class analysis was carried out on the lifetime psychotic symptoms of 554 current methamphetamine users, of whom 40 met the DSM-IV criteria for schizophrenia. Lifetime diagnoses of schizophrenia and individual psychotic symptoms were assessed using the Composite International Diagnostic Interview. The chosen model found 22% of participants had a high propensity to experience a wide range of psychotic symptoms (schizophrenia-like), whereas the majority (56%) more specifically experienced persecutory delusions and hallucinations (paranoid psychosis) and had a lower probability of these symptoms than the schizophrenia-like class. A third class (22%) had a low probability of all symptoms, with the exception of 34% reporting persecutory delusions. Participants in the schizophrenia-like class were more likely to meet diagnostic criteria for schizophrenia (26 vs. 3 and 1% for each of the other classes, p < 0.001) but the diagnosis failed to encompass 74% of this group. These results are consistent with there being a distinction between schizophrenia and methamphetamine-related psychotic symptoms, both in terms of the propensity to experience psychotic symptoms, as well as the symptomprofile; however, this distinctionmay not be captured well by existing diagnostic classifications.
Keywords: Methamphetamine; amphetamine-related disorders; psychotic disorders; schizophrenia; diagnosis; psychosis
Rights: © 2018 McKetin, Voce, Burns, Ali, Lubman, Baker and Castle. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
RMID: 0030105144
DOI: 10.3389/fpsyt.2018.00578
Grant ID: http://purl.org/au-research/grants/nhmrc/350974
Appears in Collections:Medicine publications

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