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Type: Journal article
Title: Neutrophil-initiated myocardial inflammation and Its modulation by B-type natriuretic peptide: a potential therapeutic target
Author: Liu, S.
Chirkov, Y.Y.
Horowitz, J.D.
Citation: International Journal of Molecular Sciences, 2019; 20(1):129-1-129-13
Publisher: MDPI AG
Issue Date: 2019
ISSN: 1422-0067
Statement of
Saifei Liu, Yuliy Y. Chirkov and John D. Horowitz
Abstract: Activation of neutrophils is a critically important component of the innate immune response to bacterial and chemical stimuli, and culminates in the “neutrophil burst”, which facilitates neutrophil phagocytosis via the release of superoxide anion radical (O₂-) from NADPH oxidase. Excessive and/or prolonged neutrophil activation results in substantial tissue injury and increases in vascular permeability - resulting in sustained tissue infiltration with neutrophils and monocytes, and persistent vasomotor dysfunction. Cardiovascular examples of such changes include acute and chronic systolic and diastolic heart failure (“heart failure with preserved ejection fraction”), and the catecholamine-induced inflammatory disorder takotsubo syndrome. We have recently demonstrated that B-type natriuretic peptide (BNP), acting via inhibition of activation of neutrophil NADPH oxidase, is an important negative modulator of the “neutrophil burst”, though its effectiveness in limiting tissue injury is partially lost in acute heart failure. The potential therapeutic implications of these findings, regarding the development of new means of treating both acute and chronic cardiac injury states, are discussed.
Keywords: “Neutrophil burst”; BNP; heart failure; takotsubo syndrome
Rights: © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
DOI: 10.3390/ijms20010129
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