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dc.contributor.authorHoare, S.en
dc.contributor.authorLithander, F.en
dc.contributor.authorVan Der Mei, I.en
dc.contributor.authorPonsonby, A.en
dc.contributor.authorLucas, R.en
dc.contributor.authorChapman, C.en
dc.contributor.authorCoulthard, A.en
dc.contributor.authorDear, K.en
dc.contributor.authorDwyer, T.en
dc.contributor.authorKilpatrick, T.en
dc.contributor.authorLucas, R.en
dc.contributor.authorMcMichael, T.en
dc.contributor.authorPender, M.en
dc.contributor.authorTaylor, B.en
dc.contributor.authorValery, P.en
dc.contributor.authorWilliams, D.en
dc.identifier.citationMultiple Sclerosis, 2016; 22(7):884-892en
dc.description.abstractThere is contradictory evidence for a role of dietary fat in risk of multiple sclerosis (MS).To examine the association between usual fat intake (total, saturated, monounsaturated (MUFA), polyunsaturated (PUFA), omega-3 and omega-6) and risk of a first clinical diagnosis of CNS demyelination (FCD).Multi-centre incident case-control study in four regions of Australia during 2003-2006. Cases were aged 18-59 years and had a FCD; controls were matched to a case on age, sex and location. Dietary data were collected using a validated food frequency questionnaire.In 267 cases and 517 controls with dietary data, higher intake (per g/day) of omega-3 PUFA (adjusted odds ratio, AOR=0.61 (95% CI 0.40-0.93)), and particularly that derived from fish (AOR=0.54 (95% CI 0.31-0.93)) rather than from plants (AOR=0.75 (95% CI 0.39-1.43)) was associated with a decreased risk of FCD. Total fat intake and intake of other types of fat were not associated with FCD risk.There was a significant decrease in FCD risk with higher intake of omega-3 PUFA, particularly that originating from fish. There was no evidence to indicate that the intake of other types of dietary fat or fat quantity in the previous 12 months was associated with an altered risk of FCD.en
dc.description.statementofresponsibilitySamuel Hoare, Fiona Lithander, Ingrid van der Mei, Anne-Louise Ponsonby, Robyn Lucas, for the Ausimmune Investigator Groupen
dc.publisherSAGE Publicationsen
dc.rights© The Author(s), 2015. Reprints and permissions: journalsPermissions.naven
dc.subjectMultiple sclerosis; diet; fat; saturated fat; first demyelinating event; omega-3 fatty acids; polyunsaturated fat; monounsaturated faten
dc.titleHigher intake of omega-3 polyunsaturated fatty acids is associated with a decreased risk of a first clinical diagnosis of central nervous system demyelination: results from the Ausimmune Studyen
dc.typeJournal articleen
pubs.library.collectionPublic Health publicationsen
dc.identifier.orcidDear, K. [0000-0002-0788-7404]en
Appears in Collections:Public Health publications

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