Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/118481
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Patient-reported outcomes after radiation therapy in men with prostate cancer: a systematic review of prognostic tool accuracy and validity
Author: O'Callaghan, M.E.
Raymond, E.
Campbell, J.M.
Vincent, A.D.
Beckmann, K.
Roder, D.
Evans, S.
McNeil, J.
Millar, J.
Zalcberg, J.
Borg, M.
Moretti, K.
Citation: International Journal of Radiation: Oncology - Biology - Physics, 2017; 98(2):318-337
Publisher: Elesevier
Issue Date: 2017
ISSN: 0360-3016
1879-355X
Statement of
Responsibility: 
Michael E. O’Callaghan, Elspeth Raymond, Jared M. Campbell, Andrew D. Vincent, Kerri Beckmann, David Roder, Sue Evans, John McNeil, Jeremy Millar, John Zalcberg, Martin Borg, Kim Moretti
Abstract: Purpose: To identify, through a systematic review, all validated tools used for the prediction of patient-reported outcome measures (PROMs) in patients being treated with radiation therapy for prostate cancer, and provide a comparative summary of accuracy and generalizability. Methods and Materials PubMed and EMBASE were searched from July 2007. Title/abstract screening, full text review, and critical appraisal were undertaken by 2 reviewers, whereas data extraction was performed by a single reviewer. Eligible articles had to provide a summary measure of accuracy and undertake internal or external validation. Tools were recommended for clinical implementation if they had been externally validated and found to have accuracy ≥70%. Results: The search strategy identified 3839 potential studies, of which 236 progressed to full text review and 22 were included. From these studies, 50 tools predicted gastrointestinal/rectal symptoms, 29 tools predicted genitourinary symptoms, 4 tools predicted erectile dysfunction, and no tools predicted quality of life. For patients treated with external beam radiation therapy, 3 tools could be recommended for the prediction of rectal toxicity, gastrointestinal toxicity, and erectile dysfunction. For patients treated with brachytherapy, 2 tools could be recommended for the prediction of urinary retention and erectile dysfunction. Conclusions: A large number of tools for the prediction of PROMs in prostate cancer patients treated with radiation therapy have been developed. Only a small minority are accurate and have been shown to be generalizable through external validation. This review provides an accessible catalogue of tools that are ready for clinical implementation as well as which should be prioritized for validation.
Keywords: Humans
Prostatic Neoplasms
Gastrointestinal Diseases
Urination Disorders
Urinary Retention
Prognosis
Brachytherapy
Data Collection
Retrospective Studies
Prospective Studies
Reproducibility of Results
Quality of Life
Aged
Male
Erectile Dysfunction
Patient Reported Outcome Measures
Rights: © 2017 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.ijrobp.2017.02.024
Appears in Collections:Aurora harvest 8
Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.