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Type: Journal article
Title: Paclitaxel-eluting balloon and everolimus-eluting stent for provisional stenting of coronary bifurcations: 12-month results of the multicenter BIOLUX-I study
Author: Worthley, S.
Hendriks, R.
Worthley, M.
Whelan, A.
Walters, D.
Whitbourn, R.
Meredith, I.
Citation: Cardiovascular Revascularization Medicine, 2015; 16(7):413-417
Publisher: Elsevier
Issue Date: 2015
ISSN: 1553-8389
Statement of
Stephen Worthley, Randall Hendriks, Matthew Worthley, Alan Whelan, DarrenL.Walters, Robert Whitbourn, Ian Meredith
Abstract: Several studies investigated the combination of bare metal stents in the main branch and drug-eluting balloons in the side branch in bifurcation lesions, but data on the combination of drug-eluting stents and drug-eluting balloons are scarce. We aim to assess the feasibility of provisional stenting with an everolimus-eluting stent in the main branch and a paclitaxel-eluting balloon in the side branch.In this prospective, multi-center study conducted in 5 Australian sites, 35 patients with bifurcation lesions were enrolled. Angiographic and intravascular ultrasound assessments were conducted at 9 months; clinical follow-up was conducted until 12 months.The primary endpoint, late lumen loss in the side branch measured by quantitative coronary angiography, was 0.10±0.43mm. No binary restenosis was observed. One patient died; 3 myocardial infarctions (one suspected and two in non-target vessels) and one target lesion revascularization occurred. No probable or definite stent thrombosis was observed.The combination of an everolimus-eluting stent in the main branch and a paclitaxel-eluting balloon in the side branch appears to be a safe, effective and novel treatment option for bifurcation lesions.
Keywords: Bifurcation lesion; drug-eluting balloon; drug-coated balloon; provisional stenting
Rights: © 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license ( ).
DOI: 10.1016/j.carrev.2015.07.009
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