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Type: Journal article
Title: Empirical data in support of a skin notation for methyl chloride
Author: Gaskin, S.
Thredgold, L.
Heath, L.
Pisaniello, D.
Logan, M.
Baxter, C.
Citation: Journal of Occupational and Environmental Hygiene, 2018; 15(8):569-572
Publisher: Taylor & Francis
Issue Date: 2018
ISSN: 1545-9624
Statement of
Sharyn Gaskin, Leigh Thredgold, Linda Heath, Dino Pisaniello, Michael Logan and Christina Baxter
Abstract: This article presents the first empirical experimental data on the skin absorption of methyl chloride gas using an in vitro technique and human skin. Methyl chloride is a commonly used industrial agent that is known to be an inhalational hazard but is also reported to be absorbed through human skin in amounts that contribute substantially to systemic intoxication. As a result, is has been assigned a skin notation by the ACGIH. Other than predictive models, there is a general paucity of experimental data on the skin absorption of methyl chloride and therefore a distinct lack of empirical evidence in the open literature to support the assignment of a skin notation for this chemical. This study found that methyl chloride permeates through human epidermis when exposed at high atmospheric concentrations within relatively short timeframes. Therefore, providing important initial empirical evidence in support of the assignment of a skin notation.
Keywords: Chloromethane; dermal; in vitro; methyl chloride; skin notation
Rights: © 2018 JOEH, LLC
DOI: 10.1080/15459624.2018.1470636
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