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Type: Journal article
Title: Aurones as histone deacetylase inhibitors: identification of key features
Author: Zwick, V.
Chatzivasileiou, A.-O.
Deschamps, N.
Roussaki, M.
Simões-Pires, C.A.
Nurisso, A.
Denis, I.
Blanquart, C.
Martinet, N.
Carrupt, P.-A.
Detsi, A.
Cuendet, M.
Citation: Bioorganic and Medicinal Chemistry Letters, 2014; 24(23):5497-5501
Publisher: Elsevier
Issue Date: 2014
ISSN: 0960-894X
Statement of
Vincent Zwick, Alkiviadis-Orfefs Chatzivasileiou, Nathalie Deschamps, Marina Roussaki, Claudia A. Simões-Pires ... Iza Denis ... et al.
Abstract: In this study, a total of 22 flavonoids were tested for their HDAC inhibitory activity using fluorimetric and BRET-based assays. Four aurones were found to be active in both assays and showed IC50 values below 20 μM in the enzymatic assay. Molecular modelling revealed that the presence of hydroxyl groups was responsible for good compound orientation within the isoenzyme catalytic site and zinc chelation.
Keywords: Histone deacetylase; structure activity relationship; docking; aurone
Rights: © 2014 Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.bmcl.2014.10.019
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Appears in Collections:Aurora harvest 4
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