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Type: Journal article
Title: The role of n-6 polyunsaturated fat in stable asthmatics
Author: Coates, A.
Noakes, M.
Clifton, P.
Citation: Journal of Asthma, 2001; 38(4):311-319
Publisher: Marcel Dekker Inc
Issue Date: 2001
ISSN: 0277-0903
Abstract: We investigated in a clinical setting whether increased intake of linoleic acid alters respiratory function in 26 mild asthmatics. Subjects completed a 16-week-dietary intervention comprising 8 weeks eating an enriched n-6 polyunsaturated fat diet (9.2% energy from linoleic acid) and consuming either a high monounsaturated or saturated fat diet in a random cross-over resign for 8 weeks. Neither FEV1 nor PC20 values changed significantly after increased linoleic acid consumption when compared with the other diets. Increased consumption of linoleic acid caused a 20% rise (p < or = 0.01) in plasma linoleic acid, a 38% decrease (p < or = 0.01) in plasma eicosapentaenoic acid, but no change in arachidonic acid. There were no changes in symptom scores or bronchodilator use.
Keywords: Humans; Asthma; Histamine; Margarine; Fatty Acids; Linoleic Acid; Peak Expiratory Flow Rate; Forced Expiratory Volume; Cross-Over Studies; Middle Aged; Female; Male
RMID: 0020011074
DOI: 10.1081/JAS-100002297
Appears in Collections:Physiology publications

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