Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/118690
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Type: Journal article
Title: Association between vitamin D status and hyperinsulinism
Author: McCormack, C.
Leemaqz, S.
Furness, D.
Dekker, G.
Roberts, C.
Citation: Journal of Maternal-Fetal and Neonatal Medicine, 2019; 32(23):4002-4008
Publisher: Taylor & Francis
Issue Date: 2019
ISSN: 1476-7058
1476-4954
Statement of
Responsibility: 
Catherine McCormack, Shalem Leemaqz, Denise Furness, Gustaaf Dekker and Claire Roberts
Abstract: Some studies have suggested that vitamin D deficiency is associated with an increased risk of first trimester miscarriages, others have suggested that it is associated with an increased risk of hyperinsulinism/insulin resistance and the development of gestational diabetes. Hyperinsulinism is also thought to increase miscarriages. We investigated the association between vitamin D levels and hyperinsulinism in a cohort of recurrent miscarriage patients.Patients undergoing miscarriage investigations had insulin and vitamin D levels tested. Vitamin D levels were classified as: sufficient (≥75 nmol/L), insufficient (50-74.9 nmol/L) or deficient (<50 nmol/L). Hyperinsulinism was assessed via a 75 g oral glucose tolerance test (OGTT) with insulin studies.One hundred and fifty-five patients underwent the testing. Hyperinsulinism was detected in 58.3% of the vitamin D deficient group, 38.7% of the insufficient group, and 33.3% of the sufficient group (chi-square p = .034). There were no significant associations between BMI and vitamin D levels, or BMI and hyperinsulinism. Caucasians comprised 82% of the clinic, and 67% of these women had vitamin D insufficiency/deficiency. Noncaucasians comprised 18% of the clinic but 89% of these patients had vitamin D insufficiency/deficiency.We found that insufficient or deficient vitamin D levels were significantly associated with hyperinsulinism in these patients. Vitamin D deficiency is also thought to contribute to an increased risk of adverse pregnancy outcomes including preeclampsia, preterm birth, small-for-gestational-age gestational diabetes mellitus, and miscarriages. Larger level one trials are needed to establish if increasing serum vitamin D levels prior to conception or in early pregnancy improves adverse pregnancy outcomes.
Keywords: Hyperinsulinism; insufficiency and deficiency; recurrent miscarriages; vitamin D sufficiency
Rights: © 2018 Informa UK Limited, trading as Taylor & Francis Group
RMID: 0030090513
DOI: 10.1080/14767058.2018.1481030
Grant ID: http://purl.org/au-research/grants/nhmrc/1020749
Appears in Collections:Paediatrics publications

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