Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/118772
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Type: Journal article
Title: Development and transmission of antimicrobial resistance among Gram-negative bacteria in animals and their public health impact
Author: Mukerji, S.
O'Dea, M.
Barton, M.
Kirkwood, R.
Lee, T.
Abraham, S.
Citation: Essays in Biochemistry, 2017; 61(1):23-35
Publisher: Portland Press Ltd.
Issue Date: 2017
ISSN: 0071-1365
1744-1358
Editor: Venter, H.
Statement of
Responsibility: 
Shewli Mukerji, Mark O’Dea, Mary Barton, Roy Kirkwood, Terence Lee and Sam Abraham
Abstract: Gram-negative bacteria are known to cause severe infections in both humans and animals. Antimicrobial resistance (AMR) in Gram-negative bacteria is a major challenge in the treatment of clinical infections globally due to the propensity of these organisms to rapidly develop resistance against antimicrobials in use. In addition, Gram-negative bacteria possess highly efficient mechanisms through which the AMR can be disseminated between pathogenic and commensal bacteria of the same or different species. These unique traits of Gram-negative bacteria have resulted in evolution of Gram-negative bacterial strains demonstrating resistance to multiple classes of antimicrobials. The evergrowing resistance issue has not only resulted in limitation of treatment options but also led to increased treatment costs and mortality rates in humans and animals. With few or no new antimicrobials in production to combat severe life-threatening infections, AMR has been described as the one of the most severe, long-term threats to human health. Aside from overuse and misuse of antimicrobials in humans, another factor that has exacerbated the emergence of AMR in Gram-negative bacteria is the veterinary use of antimicrobials that belong to the same classes considered to be critically important for treating serious life-threatening infections in humans. Despite the fact that development of AMR dates back to before the introduction of antimicrobials, the recent surge in the resistance towards all available critically important antimicrobials has emerged as a major public health issue. This review thus focuses on discussing the development, transmission and public health impact of AMR in Gram-negative bacteria in animals.
Keywords: Antimicrobial resistance
Rights: © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
DOI: 10.1042/EBC20160055
Appears in Collections:Animal and Veterinary Sciences publications
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