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Type: Journal article
Title: Leptin expression in offspring is programmed by nutrition in pregnancy
Author: Ekert, J.
Gatford, K.
Luxford, B.
Campbell, R.
Owens, P.
Citation: Journal of Endocrinology, 2000; 165(3):R1-R6
Publisher: Soc Endocrinology
Issue Date: 2000
ISSN: 0022-0795
Statement of
JE Eckert, KL Gatford, BG Luxford, RG Campbell, and PC Owens
Abstract: Birth weight is a determinant of blood leptin concentrations in adults. Since nutrition during pregnancy can affect birth weight, the hypothesis that feed intake during pregnancy alters leptin expression in progeny was examined. Leptin mRNA was measured in subcutaneous adipose tissue and leptin protein was measuredin blood plasma from 59 day old female pigs whose mothers were fed at the same restricted rate except that half were permitted to consume 35% more feed during the second quarter of pregnancy. Leptin mRNA abundance in adipose tissue (P=0.015) and plasma leptin concentration (P=0.01) were higher in progeny from mothers provided with more feed. Body weight at birth was negatively correlated with the abundance of leptin mRNA in subcutaneous fat at 59 days of age (P=0.01). This study shows for the first time that maternal nutrition during pregnancy programs postnatal leptin expression in offspring.
Keywords: Adipose Tissue; Animals; Prenatal Exposure Delayed Effects; Birth Weight; Leptin; RNA, Messenger; Reverse Transcriptase Polymerase Chain Reaction; Pregnancy; Pregnancy, Animal; Female; Animal Nutritional Physiological Phenomena
Rights: © 2000 by Society for Endocrinology
RMID: 0001001675
DOI: 10.1677/joe.0.165R001
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Appears in Collections:Physiology publications

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