Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/118916
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Type: Book chapter
Title: Peptides as bio-inspired molecular electronic materials
Author: Horsley, J.
Yu, J.
Yeoh, Y.
Abell, A.
Citation: Peptides and Peptide-based Biomaterials and their Biomedical Applications, 2017 / Sunna, A., Care, A., Berquist, P.L. (ed./s), Ch.6, pp.131-153
Publisher: Springer, Cham
Publisher Place: Switzerland
Issue Date: 2017
Series/Report no.: Advances in Experimental Medicine and Biology
ISBN: 9783319660943
Statement of
Responsibility: 
John Horsley, Jingxian Yu, Yuan Qi Yeoh, and Andrew Abell
Abstract: Understanding the electronic properties of single peptides is not only of fundamental importance to biology, but it is also pivotal to the realization of bio-inspired molecular electronic materials. Natural proteins have evolved to promote electron transfer in many crucial biological processes. However, their complex conformational nature inhibits a thorough investigation, so in order to study electron transfer in proteins, simple peptide models containing redox active moieties present as ideal candidates. Here we highlight the importance of secondary structure characteristic to proteins/peptides, and its relevance to electron transfer. The proposed mechanisms responsible for such transfer are discussed, as are details of the electrochemical techniques used to investigate their electronic properties. Several factors that have been shown to influence electron transfer in peptides are also considered. Finally, a comprehensive experimental and theoretical study demonstrates that the electron transfer kinetics of peptides can be successfully fine tuned through manipulation of chemical composition and backbone rigidity. The methods used to characterize the conformation of all peptides synthesized throughout the study are outlined, along with the various approaches used to further constrain the peptides into their geometric conformations. The aforementioned sheds light on the potential of peptides to one day play an important role in the fledgling field of molecular electronics.
Keywords: Peptides; Electron transfer; Bio-inspired; Molecular electronics; Electronic materials; Electrochemical methods
Rights: © Springer International Publishing AG 2017
RMID: 0030077000
DOI: 10.1007/978-3-319-66095-0_6
Appears in Collections:Chemistry and Physics publications

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