Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/118990
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Type: Journal article
Title: Epidemiology of infertility in China: a population-based study
Author: Zhou, Z.
Zheng, D.
Wu, H.
Li, R.
Xu, S.
Kang, Y.
Cao, Y.
Chen, X.
Zhu, Y.
Xu, S.
Chen, Z.
Mol, B.
Qiao, J.
Citation: BJOG: an International Journal of Obstetrics and Gynaecology, 2018; 125(4):432-441
Publisher: Wiley
Issue Date: 2018
ISSN: 1470-0328
1471-0528
Statement of
Responsibility: 
Z Zhou, D Zheng, H Wu, R Li, S Xu, Y Kang, Y Cao, X Chen, Y Zhu, S Xu, Z-J Chen, BW Mol, J Qiao
Abstract: Objective: To assess the current prevalence of and risk factors for infertility among couples of reproductive age in China. Design: Population-based cross-sectional study. Setting: We approached 25,270 couples in eight provinces/municipalities, of whom 18,571 (response rate 74%) were interviewed. Population: Couples living together and married for more than 1 year, of whom the female spouse was 20-49 years old. Methods: Women were approached via telephone and face-to-face conversation to complete the standardised and structured questionnaire by trained interviewers. Main Outcome Measures: Prevalence of and risk factors for infertility. Results: Among women 'at risk' of pregnancy, the prevalence of infertility was 15.5% (2680/17 275). Among 10 742 women attempting to become pregnant, the prevalence of infertility was 25.0% (2680/10 742), which increased with age in the second population. Among women who failed to achieve pregnancy in the last 12 months, 3470 finished our questionnaire about fertility care, and 55.2% (1915/3470) of them had sought medical help. Sociodemographic risk factors for infertility included lower educational level [adjusted odds ratio (aOR) 3.4, 95% CI 2.0-5.5] and employment (aOR 2.3, 95% CI 1.9-2.9). Clinical risk factors were irregular menstrual cycle (aOR 1.8, 95% CI 1.2-2.5), light menstrual blood volume (aOR 1.6, 95% CI 1.2-2.0), history of cervicitis (aOR 1.5, 95% CI 1.2-2.0) and endometriosis (aOR 3.1, 95% CI 1.1-9.3), previous stillbirth (aOR 2.1, 95% CI 1.3-3.3) and miscarriage (aOR 2.7, 95% CI 2.1-3.5). In addition, history of operation was a significant risk factor of infertility. Conclusions: Among couples of reproductive age in China, the prevalence of infertility was 25%, and almost half of the couples experiencing infertility had not sought medical help
Keywords: Epidemiology; infertility; medical help; prevalence; risk factors
Rights: © 2017 Royal College of Obstetricians and Gynaecologists
DOI: 10.1111/1471-0528.14966
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