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https://hdl.handle.net/2440/11902
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Type: | Journal article |
Title: | Conservation of surfactant protein a: evidence for a single origin for vertebrate pulmonary surfactant |
Author: | Sullivan, Lucy C. Daniels, Christopher Brian Phillips, Ian D. Orgeig, Sandra Whitsett, Jeffrey A. |
Citation: | Journal of Molecular Evolution, 1998; 46(46):131-138 |
Issue Date: | 1998 |
ISSN: | 0022-2844 |
Statement of Responsibility: | Lucy C. Sullivan, Christopher B. Daniels, Ian D. Phillips, Sandra Orgeig, Jeffrey A. Whitsett |
Abstract: | Surface tension is reduced at the air–liquid interface in the lung by a mixture of lipids and proteins termed pulmonary surfactant. This study is the first to provide evidence for the presence of a surfactant-specific protein (Surfactant Protein A—SP-A) in the gas-holding structures of representatives of all the major vertebrate groups. Western blot analysis demonstrated cross-reactivity between an antihuman SP-A antibody and material lavaged from lungs or swimbladders of members from all vertebrate groups. Immunocytochemistry localized this SP-A–like protein to the air spaces of lungs from the actinopterygiian fish and lungfish. Northern blot analysis indicated that regions of the mouse SP-A cDNA sequence are complementary to lung mRNA from all species examined. The presence of an SP-A–like protein and SP-A mRNA in members of all the major vertebrate groups implies that the surfactant system had a single evolutionary origin in the vertebrates. Moreover, the evolution of the surfactant system must have been a prerequisite for the evolution of airbreathing. The presence of SP-A in the goldfish swimbladder demonstrates a role for the surfactant system in an organ that is no longer used for airbreathing. |
Keywords: | Pulmonary surfactant; Surfactant protein A; Evolution; Vertebrate; Airbreathing; Surface tension |
DOI: | 10.1007/PL00006287 |
Appears in Collections: | Physiology publications |
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