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Type: Journal article
Title: Imaging of tumor characteristics and molecular pathways with PET: developments over the last decade toward personalized cancer therapy
Author: Marcu, L.
Moghaddasi, L.
Bezak, E.
Citation: International Journal of Radiation: Oncology - Biology - Physics, 2018; 102(4):1165-1182
Publisher: Elsevier
Issue Date: 2018
ISSN: 0360-3016
Statement of
Loredana Gabriela Marcu, Leyla Moghaddasi and Eva Bezak
Abstract: Purpose: Improvements in personalized therapy are made possible by the advances in molecular biology that led to developments in molecular imaging, allowing highly specific in vivo imaging of biological processes. Positron emission tomography (PET) is the most specific and sensitive imaging technique for in vivo molecular targets and pathways, offering quantification and evaluation of functional properties of the targeted anatomy. Materials and Methods: This work is an integrative research review that summarizes and evaluates the accumulated current status of knowledge of recent advances in PET imaging for cancer diagnosis and treatment, concentrating on novel radiotracers and evaluating their advantages and disadvantages in cancer characterization. Medline search was conducted, limited to English publications from 2007 onward. Identified manuscripts were evaluated for most recent developments in PET imaging of cancer hypoxia, angiogenesis, proliferation, and clonogenic cancer stem cells (CSC). Results: There is an expansion observed from purely metabolic-based PET imaging toward antibody-based PET to achieve more information on cancer characteristics to identify hypoxia, proangiogenic factors, CSC, and others. 64Cu-ATSM, for example, can be used both as a hypoxia and a CSC marker. Conclusions: Progress in the field of functional imaging will possibly lead to more specific tumor targeting and personalized treatment, increasing tumor control and improving quality of life.
Keywords: Humans
Neovascularization, Pathologic
Radioactive Tracers
Positron-Emission Tomography
Precision Medicine
Tumor Hypoxia
Rights: © 2018 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.ijrobp.2018.04.055
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