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https://hdl.handle.net/2440/119135
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dc.contributor.author | Augustine, P. | - |
dc.contributor.author | Gent, R. | - |
dc.contributor.author | Louise, J. | - |
dc.contributor.author | Taranto, M. | - |
dc.contributor.author | Penno, M. | - |
dc.contributor.author | Linke, R. | - |
dc.contributor.author | Couper, J. | - |
dc.contributor.author | ENDIA Study Group, | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Diabetic Medicine, 2020; 37(8):1340-1343 | - |
dc.identifier.issn | 0742-3071 | - |
dc.identifier.issn | 1464-5491 | - |
dc.identifier.uri | http://hdl.handle.net/2440/119135 | - |
dc.description.abstract | AIMS:To measure pancreatic area and exocrine function in young children with recent-onset Type 1 diabetes to determine whether the exocrine pancreas is also affected in the pathophysiology of early childhood diabetes. METHODS:Thirty-two children (14 boys) aged 5.5 (4.5, 7.3) median (IQR) years presenting with recent-onset Type 1 diabetes and 90 controls (44 boys) of similar age had ultrasound imaging of the pancreas. Children with Type 1 diabetes were receiving insulin and were without ketosis. Transverse and longitudinal areas of the pancreas were measured by digitalized outline. Pancreatic faecal elastase-1 was analysed using an enzyme-linked immunosorbent assay kit in recent-onset Type 1 diabetes and 38 first-degree relative control children. RESULTS:Pancreatic area and exocrine function were reduced in Type 1 diabetes. Mean transverse area (SD) in Type 1 diabetes was 6.82 cm2 (1.61) vs. 8.31 cm2 (1.74) in controls, adjusted estimate (95% CI) 1.45 (-2.12, -0.79), P < 0.001; longitudinal area was 1.28 cm2 (0.44) vs. 1.55 cm2 (0.43), adjusted estimate (95% CI) -0.27 (-0.45, -0.09), P = 0.003. Faecal elastase-1 levels in Type 1 diabetes were 455 (323, 833) ug/g, median (IQR) vs. 1408 μg/g (1031, 1989) in controls, P < 0.001. CONCLUSION:Pancreatic area and accompanying subclinical exocrine function were reduced in very young children with recent-onset Type 1 diabetes. This supports changes in the exocrine pancreas in the pathophysiology of Type 1 diabetes presenting in early life. | - |
dc.description.statementofresponsibility | P. Augustine, R. Gent, J. Louise, M. Taranto, M. Penno, R. Linke and J. J. Couper, on behalf of the ENDIA Study Group | - |
dc.language.iso | en | - |
dc.publisher | Wiley | - |
dc.rights | © 2019 Diabetes UK | - |
dc.source.uri | http://dx.doi.org/10.1111/dme.13987 | - |
dc.subject | ENDIA Study Group | - |
dc.title | Pancreas size and exocrine function is decreased in young children with recent-onset Type 1 diabetes | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/dme.13987 | - |
dc.relation.grant | NHMRC | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Louise, J. [0000-0001-5785-0290] | - |
dc.identifier.orcid | Penno, M. [0000-0002-9617-0826] | - |
dc.identifier.orcid | Couper, J. [0000-0003-4448-8629] | - |
Appears in Collections: | Aurora harvest 8 Medicine publications |
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