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Type: Journal article
Title: High rates of indeterminate interferon-gamma release assays for the diagnosis of latent tuberculosis infection in liver transplantation candidates
Author: Wigg, A.
Narayana, S.
Anwar, S.
Ramachandran, J.
Muller, K.
Chen, J.
John, L.
Hissaria, P.
Kaambwa, B.
Woodman, R.
Citation: Transplant Infectious Disease, 2019; OnlinePubl(3):e13087
Publisher: John Wiley & Sons
Issue Date: 2019
ISSN: 1398-2273
Statement of
Alan J. Wigg, Sumudu K. Narayana, Shahzaib Anwar, Jeyamani Ramachandran, Kate Muller, John W. Chen, Libby John, Pravin Hissaria, Billingsley Kaambwa, Richard J. Woodman
Abstract: BACKGROUND AND AIMS:Screening for latent tuberculosis infection (LTBI) is recommended prior to solid organ transplantation. Interferon-gamma release assays (IGRAs) are the most widely used test for LTBI screening; however, assessment of IGRA performance in patients with end-stage liver disease is limited. The purpose of this study was to evaluate the prevalence and predictors of indeterminate (INDT) IGRA results in liver transplantation candidates. METHODS:Between March 2011 and May 2018, we retrospectively analyzed 155 patients undergoing liver transplantation assessment, who underwent IGRA testing (Quantiferon-TB Gold, QFT-G) to exclude LTBI. Characteristics of patients, including age, gender, etiology of liver disease, MELD score, and absolute lymphocyte counts, were compared by QFT-G result (determinate vs INDT). RESULTS:Of the 155 patients screened, the rate of positive, negative, and INDT results were 5.2%, 69.8%, and 25%, respectively. The only variable independently associated with an indeterminate test on multivariate analysis was MELD score (odds ratio = 1.07, 95% CI = 1.01-1.14 per unit increase; P = 0.014). In 95% of INDT tests, both TB antigen tube and the positive control tube were negative and repeat testing gave the same indeterminate result, suggestive of anergy rather than laboratory error. CONCLUSIONS:Our study suggests a high rate of INDT IGRA results during screening of liver transplant candidates for LTBI, associated with severity of liver disease and anergy. Because of the high rate of INDT QFT-G testing in this setting, individualized risk assessment is required including a thorough assessment of clinical risk factors and knowledge of local TB prevalence.
Keywords: anergy; indeterminate; interferon-gamma release assay; latent tuberculosis; liver transplantation
Rights: © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
RMID: 0030113524
DOI: 10.1111/tid.13087
Appears in Collections:Medicine publications

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