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Type: Journal article
Title: Trefoil factor family: unresolved questions and clinical perspectives
Author: Braga Emidio, N.
Hoffmann, W.
Brierley, S.
Muttenthaler, M.
Citation: Trends in Biochemical Sciences, 2019; 44(5):387-390
Publisher: Elsevier
Issue Date: 2019
ISSN: 0968-0004
Statement of
Nayara Braga Emidio, Werner Hoffmann, Stuart M.Brierley, Markus Muttenthaler
Abstract: The trefoil factor family of peptides (TFF1, TFF2, TFF3) with their lectin activities play important roles in mucosal protection and repair. However, major gaps in understanding their molecular function have hampered therapeutic development for gastrointestinal disorders. We provide here a critical overview of the status quo.
Keywords: cell migration
gastrointestinal wound healing
mucosal protection
Rights: © 2019 Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.tibs.2019.01.004
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