Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/119409
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Type: Journal article
Title: The role of mitochondrial DNA copy number, variants, and haplotypes in farm animal developmental outcome
Author: Tsai, T.
St John, J.
Citation: Domestic Animal Endocrinology, 2016; 56:S133-S146
Publisher: Elsevier
Issue Date: 2016
ISSN: 0739-7240
1879-0054
Statement of
Responsibility: 
TeshaTsai, Justin C.St. John
Abstract: The vast majority of cellular energy is generated through the process of oxidative phosphorylation, which takes place in the electron transport chain in the mitochondria. The electron transport chain is encoded by 2 genomes, the chromosomal and the mitochondrial genomes. Mitochondrial DNA is associated with a number of traits, which include tolerance to heat, growth and physical performance, meat and milk quality, and fertility. Mitochondrial genomes can be clustered into groups known as mtDNA haplotypes. Mitochondrial DNA haplotypes are a potential genetic source for manipulating phenotypes in farm animals. The use of assisted reproductive technologies, such as nuclear transfer, allows favorable chromosomal genetic traits to be mixed and matched with sought after mtDNA haplotype traits. As a result super breeds can be generated.
Keywords: Mitochondrial DNA; haplotype; development; genetic diversity; somatic cell nuclear transfer
Rights: © 2016 Elsevier Inc. All rights reserved.
RMID: 0030112557
DOI: 10.1016/j.domaniend.2016.03.005
Grant ID: http://purl.org/au-research/grants/nhmrc/1041471
Appears in Collections:Animal and Veterinary Sciences publications

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