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https://hdl.handle.net/2440/119475
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Type: | Journal article |
Title: | The effects of long-term CPAP on weight change in patients with comorbid OSA and cardiovascular disease: data from the SAVE trial |
Author: | Ou, Q. Chen, B. Loffler, K.A. Luo, Y. Zhang, X. Chen, R. Wang, Q. Drager, L.F. Lorenzi-Filho, G. Hlavac, M. McArdle, N. Mukherjee, S. Mediano, O. Barbe, F. Anderson, C.S. McEvoy, R.D. Woodman, R.J. |
Citation: | Chest, 2019; 155(4):720-729 |
Publisher: | Elsevier |
Issue Date: | 2019 |
ISSN: | 0012-3692 1931-3543 |
Statement of Responsibility: | Qiong Ou, Baixin Chen, Kelly A. Loffler, Yuanming Luo, Xilong Zhang, Rui Chen, Qian Wang, Luciano F. Drager, Geraldo Lorenzi-Filho, Michael Hlavac, Nigel McArdle, Sutapa Mukherjee, Olga Mediano, Ferran Barbe, Craig S. Anderson, R. Doug McEvoy, Richard J. Woodman (on behalf of the SAVE investigators) |
Abstract: | Background: Although recent evidence suggests that OSA treatment may cause weight gain, the long-term effects of CPAP on weight are not well established. Methods: This study was a post hoc analysis of the Sleep Apnea Cardiovascular Endpoints (SAVE) study, a multicenter, randomized trial of CPAP plus standard care vs standard care alone in adults with a history of cardiac or cerebrovascular events and moderate to severe OSA. Participants with weight, BMI, and neck and waist circumferences measured at baseline and during follow-up were included. Linear mixed models were used to examine sex-specific temporal differences, and a sensitivity analysis compared high CPAP adherers (≥ 4 h per night) with propensity-matched control participants. Results: A total of 2,483 adults (1,248 in the CPAP group and 1,235 in the control group) were included (mean 6.1 ± 1.5 measures of weight available). After a mean follow-up of 3.78 years, there was no difference in weight change between the CPAP and control groups, for male subjects (mean [95% CI] between-group difference, 0.07 kg [-0.40 to 0.54]; P = .773) or female subjects (mean [95% CI] between-group difference, -0.14 kg [-0.37 to 0.09]; P = .233). Similarly, there were no significant differences in BMI or other anthropometric measures. Although male participants who used CPAP ≥ 4 h per night gained slightly more weight than matched male control subjects without CPAP (mean difference, 0.38 kg [95% CI, 0.04 to 0.73]; P = .031), there were no between-group differences in other anthropometric variables, nor were there any differences between female high CPAP adherers and matched control subjects. Conclusions: Long-term CPAP use in patients with comorbid OSA and cardiovascular disease does not result in clinically significant weight change. |
Keywords: | CPAP; long-term; OSA; weight |
Rights: | © 2018 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved. |
DOI: | 10.1016/j.chest.2018.08.1082 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1006501 http://purl.org/au-research/grants/nhmrc/1060078 |
Published version: | http://dx.doi.org/10.1016/j.chest.2018.08.1082 |
Appears in Collections: | Aurora harvest 8 Medicine publications |
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