Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/11957
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dc.contributor.authorMcMillen, I.en
dc.contributor.authorPhillips, I.en
dc.contributor.authorRoss, J.en
dc.contributor.authorRobinson, J.en
dc.contributor.authorOwens, J.en
dc.date.issued1995en
dc.identifier.citationReproduction, Fertility and Development, 1995; 7(3):499-507en
dc.identifier.issn1031-3613en
dc.identifier.issn1448-5990en
dc.identifier.urihttp://hdl.handle.net/2440/11957-
dc.description.abstractIt is clear that the timing of parturition is dependent on a cascade of endocrine signals from an intact fetal hypothalamo-pituitary-adrenal axis. What is not known, however is the nature or source of the central neural stimulation which results in the stimulation of adrenocorticotrophic hormone (ACTH) synthesis and secretion in late gestation. The changes which occur in the synthesis and posttranslational processing of the ACTH precursor, proopiomelanocortin (POMC), in the fetal anterior pituitary before birth and the consequence of these changes for expression of the corticosteroidogenic enzymes in the fetal adrenal are described in this review. Evidence for the functional heterogeneity of corticotrophic cell types in the fetal sheep pituitary and the proposal that there is a maturational change in the populations of corticotrophic cells in late gestation are discussed. Finally, the development of cortisol negative feedback in the late gestation fetal hypothalamo-pituitary axis and the relevance of chronic stress to the timing of parturition are also dicussed.en
dc.description.statementofresponsibilityIC McMillen, ID Phillips, JT Ross, JS Robinson and JA Owensen
dc.language.isoenen
dc.publisherC S I R O PUBLICATIONSen
dc.rights© CSIRO 1995en
dc.subjectHypothalamus, pituitary, adrenal, fetus, proopiomelanocortin, ACTH, cortisol, corticotrophin-releasing factor, arginine vasopressin, hypoglycaemia, corticotrophen
dc.titleChronic stress - the key to parturition?en
dc.typeJournal articleen
dc.identifier.rmid0030004077en
dc.identifier.doi10.1071/RD9950499en
dc.identifier.pubid68083-
pubs.library.collectionPhysiology publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidRoss, J. [0000-0001-7243-1051]en
dc.identifier.orcidRobinson, J. [0000-0002-4515-6039]en
dc.identifier.orcidOwens, J. [0000-0002-7498-1353]en
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