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Type: Journal article
Title: Dietary supplementation with orange juice and carrot juice in cigarette smokers lowers oxidation products in copper oxidised low density lipoproteins
Author: Abbey, M.
Noakes, M.
Nestel, P.
Citation: Journal of the American Dietetics Association, 1995; 95(6):671-675
Publisher: The Association
Issue Date: 1995
ISSN: 0002-8223
Abstract: <h4>Objective</h4>Our objective was to evaluate the effect of daily supplementation with foods high in vitamin C and beta carotene on plasma vitamin levels and oxidation of low-density lipoprotein (LDL) in cigarette smokers.<h4>Subjects</h4>Fifteen normolipidemic male cigarette smokers who did not usually take vitamin supplements were recruited into the study.<h4>Interventions</h4>Throughout the study, subjects consumed a diet rich in polyunsaturated fatty acids, which provided 36% of energy as fat: 18% from meat, dairy products, vegetable oils, and fat spreads and 18% from walnuts (68 g/day). Subjects consumed a vitamin-free drink daily for 3 weeks; then for 3 weeks they consumed daily supplements of orange juice (145 mg vitamin C) and carrot juice (16 mg beta carotene).<h4>Results</h4>Vitamin-rich food supplements raised plasma levels of ascorbic acid (1.6-fold; P < .01) and beta carotene (2.6-fold; P < .01). Malondialdehyde, one end product of oxidation, was lower in copper-oxidized LDL after vitamin supplementation (mean +/- standard error = 65.7 +/- 2.0 and 57.5 +/- 2.9 mumol/g LDL protein before and after supplementation, respectively; P < .01). Rate of LDL oxidation and lag time before the onset of LDL oxidation were not affected by antioxidant supplementation.<h4>Conclusions</h4>In habitual cigarette smokers, antioxidant vitamins, which can be feasibly provided from food, partly protected LDL from oxidation despite a diet rich in polyunsaturated fatty acids.
Keywords: Humans; Daucus carota; Citrus; Copper; Malondialdehyde; Ascorbic Acid; Carotenoids; beta Carotene; Lipids; Cholesterol, Dietary; Fatty Acids; Fatty Acids, Unsaturated; Lipoproteins, LDL; Diet; Smoking; Oxidation-Reduction; Beverages; Food, Fortified; Adult; Middle Aged; Diet Records; Male
RMID: 0030004076
DOI: 10.1016/S0002-8223(95)00183-2
Appears in Collections:Physiology publications

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