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https://hdl.handle.net/2440/119605
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dc.contributor.author | Harbison, J.E. | - |
dc.contributor.author | Roth-Schulze, A.J. | - |
dc.contributor.author | Giles, L.C. | - |
dc.contributor.author | Tran, C.D. | - |
dc.contributor.author | Ngui, K.M. | - |
dc.contributor.author | Penno, M.A. | - |
dc.contributor.author | Thomson, R.L. | - |
dc.contributor.author | Wentworth, J.M. | - |
dc.contributor.author | Colman, P.G. | - |
dc.contributor.author | Craig, M.E. | - |
dc.contributor.author | Morahan, G. | - |
dc.contributor.author | Papenfuss, A.T. | - |
dc.contributor.author | Barry, S.C. | - |
dc.contributor.author | Harrison, L.C. | - |
dc.contributor.author | Couper, J.J. | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Pediatric Diabetes, 2019; 20(5):574-583 | - |
dc.identifier.issn | 1399-543X | - |
dc.identifier.issn | 1399-5448 | - |
dc.identifier.uri | http://hdl.handle.net/2440/119605 | - |
dc.description.abstract | AIMS/HYPOTHESIS:To investigate the longitudinal relationship between the gut microbiome, circulating short chain fatty acids (SCFAs) and intestinal permeability in children with islet autoimmunity or type 1 diabetes and controls. METHODS:We analyzed the gut bacterial microbiome, plasma SCFAs, small intestinal permeability and dietary intake in 47 children with islet autoimmunity or recent-onset type 1 diabetes and in 41 unrelated or sibling controls over a median (range) of 13 (2-34) months follow-up. RESULTS:Children with multiple islet autoantibodies (≥2 IA) or type 1 diabetes had gut microbiome dysbiosis. Anti-inflammatory Prevotella and Butyricimonas genera were less abundant and these changes were not explained by differences in diet. Small intestinal permeability measured by blood lactulose:rhamnose ratio was higher in type 1 diabetes. Children with ≥2 IA who progressed to type 1 diabetes (progressors), compared to those who did not progress, had higher intestinal permeability (mean [SE] difference +5.14 [2.0], 95% confidence interval [CI] 1.21, 9.07, P = .006), lower within-sample (alpha) microbial diversity (31.3 [11.2], 95% CI 9.3, 53.3, P = .005), and lower abundance of SCFA-producing bacteria. Alpha diversity (observed richness) correlated with plasma acetate levels in all groups combined (regression coefficient [SE] 0.57 [0.21], 95% CI 0.15, 0.99 P = .008). CONCLUSIONS/INTERPRETATION:Children with ≥2 IA who progress to diabetes, like those with recent-onset diabetes, have gut microbiome dysbiosis associated with increased intestinal permeability. Interventions that expand gut microbial diversity, in particular SCFA-producing bacteria, may have a role to decrease progression to diabetes in children at-risk. | - |
dc.description.statementofresponsibility | Lynne C. Giles, Cuong D. Tran ... Megan A. Penno, Rebecca L. Thomson ... Simon C Barry ... Jennifer J. Couper ... et al. | - |
dc.language.iso | en | - |
dc.publisher | Wiley Online Library | - |
dc.rights | © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. | - |
dc.source.uri | http://dx.doi.org/10.1111/pedi.12865 | - |
dc.subject | gut microbiome | - |
dc.subject | intestinal permeability | - |
dc.subject | islet autoimmunity | - |
dc.subject | short chain fatty acids | - |
dc.subject | type 1 diabetes | - |
dc.title | Gut microbiome dysbiosis and increased intestinal permeability in children with islet autoimmunity and type 1 diabetes: a prospective cohort study | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/pedi.12865 | - |
dc.relation.grant | NHMRC | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Giles, L.C. [0000-0001-9054-9088] | - |
dc.identifier.orcid | Tran, C.D. [0000-0001-9220-2715] | - |
dc.identifier.orcid | Penno, M.A. [0000-0002-9617-0826] | - |
dc.identifier.orcid | Thomson, R.L. [0000-0002-7807-4144] | - |
dc.identifier.orcid | Barry, S.C. [0000-0002-0597-7609] | - |
dc.identifier.orcid | Couper, J.J. [0000-0003-4448-8629] | - |
Appears in Collections: | Aurora harvest 4 Paediatrics publications |
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