Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/119664
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Type: Journal article
Title: Germline variation at 8q24 and prostate cancer risk in men of European ancestry
Author: Matejcic, M.
Saunders, E.
Dadaev, T.
Brook, M.
Wang, K.
Sheng, X.
Olama, A.
Schumacher, F.
Ingles, S.
Govindasami, K.
Benlloch, S.
Berndt, S.
Albanes, D.
Koutros, S.
Muir, K.
Stevens, V.
Gapstur, S.
Tangen, C.
Batra, J.
Clements, J.
et al.
Citation: Nature Communications, 2018; 9(1):4616-1-4616-11
Publisher: Springer Nature
Issue Date: 2018
ISSN: 2041-1723
2041-1723
Statement of
Responsibility: 
Marco Matejcic … Lisa Butler … Pamela Saunders … Wayne Tilley … et al.
Abstract: Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation at 8q24 to prostate cancer risk. We identify 12 independent risk signals for prostate cancer (p < 4.28 × 10⁻¹⁵), including three risk variants that have yet to be reported. From a polygenic risk score (PRS) model, derived to assess the cumulative effect of risk variants at 8q24, men in the top 1% of the PRS have a 4-fold (95%CI = 3.62-4.40) greater risk compared to the population average. These 12 variants account for ~25% of what can be currently explained of the familial risk of prostate cancer by known genetic risk factors. These findings highlight the overwhelming contribution of germline variation at 8q24 on prostate cancer risk which has implications for population risk stratification.
Keywords: PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium
Rights: © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
RMID: 0030107726
DOI: 10.1038/s41467-018-06863-1
Appears in Collections:Medicine publications

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