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Type: Journal article
Title: Evolution of androgen deprivation therapy
Author: Raj, G.
Selth, L.
Day, T.
Tilley, W.
Citation: Cancer Forum, 2015; 39(3):189-194
Publisher: The Cancer Council Australia
Issue Date: 2015
ISSN: 0311-306X
Statement of
Ganesh V Raj, Luke A Selth, Tanya K Day, Wayne D Tilley
Abstract: The androgen signalling axis is critical for the development and progression of prostate cancer. Therefore, the mainstay treatments for metastatic disease are hormonal manipulations aimed at reducing androgen levels and/ or blocking the androgen receptor, collectively termed androgen deprivation therapy. This review will discuss the evolution of androgen deprivation therapy since it was instigated more than 70 years ago, and outline the key mechanisms underlying its inevitable failure. We will also briefly introduce potential new androgen signallingtargeted therapies in clinical development.
Keywords: Cancer--mortality; androgens--therapeutic use; prostate--cancer--patients; androgens--receptors
Rights: © Cancer Council of Australia
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