Please use this identifier to cite or link to this item:
|Title:||Breast cancer susceptibility gene 1 (BRCA1) is a coactivator of the androgen receptor|
|Citation:||Cancer Research, 2000; 60(21):5946-5949|
|Publisher:||American Association for Cancer Research|
|J.J. Park, R. A. Irvine, G. Buchanan, S. S. Koh, J. M. Park ... Wayne D. Tilley ... et al.|
|Abstract:||In the present study, the role of BRCA1 in ligand-dependent androgen receptor (AR) signaling was assessed. In transfected prostate and breast cancer cell lines, BRCA1 enhanced AR-dependent transactivation of a probasin-derived reporter gene. The effects of BRCA1 were mediated through the NH2-terminal activation function (AF-1) of the receptor. Cotransfection of p160 coactivators markedly potentiated BRCA1-mediated enhancement of AR signaling. In addition, BRCA1 was shown to interact physically with both the AR and the p160 coactivator, glucocorticoid receptor interacting protein 1. These findings suggest that BRCA1 may directly modulate AR signaling and, therefore, may have implications regarding the proliferation of normal and malignant androgen-regulated tissues.|
|Keywords:||Prostate-cancer; proteins; domains; cells|
|Rights:||Copyright status unknown|
|Appears in Collections:||Aurora harvest 4|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.