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Type: Journal article
Title: Immunolocalization of apolipoprotein d, androgen receptor and prostate specific antigen in early stage prostate cancers
Author: Zhang, S.X.D.
Bentel, J.M.
Ricciardelli, C.
Horsfall, D.J.
Haagensen, D.E.
Marshall, V.R.
Tilley, W.D.
Citation: The Journal of Urology, 1998; 159(2):548-554
Publisher: Elsevier
Issue Date: 1998
ISSN: 0022-5347
Statement of
Steven X.D. Zhang, Jacqueline M. Bentel, Carmela Ricciardelli, David J. Horsfall, Darrow E. Haagensen, Villis R. Marshall and Wayne D. Tilley
Abstract: PURPOSE: To determine the cellular distribution and levels of immunohistochemical staining for apolipoprotein D (Apo-D), prostate specific antigen (PSA) and androgen receptor (AR) in early stage prostate cancers. MATERIALS AND METHODS: Cellular distribution of Apo-D, PSA and AR in 30 stage A/B prostate cancers and in non-malignant glandular tissue contained in the same sections was detected immunohistochemically, and staining was evaluated by computerized video image analysis. RESULTS: Staining for Apo-D (percentage positive cellular area) was significantly increased in tumor cells of early stage prostate cancers compared with non-malignant glandular tissue. PSA and AR were present at high levels in both early stage prostate tumors and non-malignant prostate. CONCLUSIONS: Malignant transformation in the prostate is associated with increased cellular levels of Apo-D.
Keywords: Apolipoproteins D
Rights: © 1998 by American Urological Association, Inc.
DOI: 10.1016/S0022-5347(01)63981-8
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