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Type: Journal article
Title: Steroid hormone and epidermal growth factor receptors in meningiomas
Author: Horsfall, D.
Goldsmith, K.
Ricciardelli, C.
Skinner, J.
Tilley, W.
Marshall, V.
Citation: ANZ Journal of Surgery, 1989; 59(11):881-888
Publisher: Wiley Online Library
Issue Date: 1989
ISSN: 0004-8682
Statement of
David J. Horsfall, Kimberly G. Goldsmith, Carmela Ricciardelli, John M. Skinner, Wayne D. Tilley, Villis R. Marshall
Abstract: A prospective study of steroid hormone and epidermal growth factor receptor expression in 57 meningiomas is presented. Scatchard analysis of radioligand binding identified 20% of meningiomas as expressing classical oestrogen receptors (ER) at levels below that normally accepted for positivity, the remainder being negative. ER could not be visualized in any meningioma using immunocytochemistry. Alternatively, 74% of meningiomas demonstrated the presence of progesterone receptors (PR) by Scatchard analysis, the specificity of which could not be attributed to glucocorticoid or androgen receptors. Confirmation of classical PR presence was determined by immunocytochemical staining. The presence of epidermal growth factor receptor (EGFR) was demonstrated in 100% of meningiomas using immunocytochemical staining. These data are reviewed in the context of previously reported results and are discussed in relation to the potential for medical therapy as an adjunct to surgery.
Keywords: Epidermal growth factor receptor; immunocytocbemistry; meningioma; oestrogen receptor; progesterane receptor; scatchard analysis
Rights: Copyright status unknown
DOI: 10.1111/j.1445-2197.1989.tb07033.x
Appears in Collections:Aurora harvest 4
Medicine publications

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