Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/11978
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Type: Journal article
Title: Colonic mechanoreceptor inputs to rat lumbo-sacral dorsal horn neurones: distribution, thresholds and chemosensory modulation
Author: Andrew, L.
Blackshaw, L.
Citation: Neurogastroenterology and Motility, 2001; 13(4):333-337
Publisher: Blackwell Science Ltd
Issue Date: 2001
ISSN: 1350-1925
1365-2982
Abstract: In order to better understand the central processing of visceral sensory information, we studied the responses of lumbo-sacral dorsal horn (L4-S1) neurones to colonic stimuli in anaesthetized rats. Twenty-four neurones responded to distal colonic distension with a 2.5-cm balloon; six of these were tested with proximal colonic distension, to which none responded. All neurones tested responded to somatic non-noxious inputs (tail movement). Responses to colonic distension were excitatory (n=22) or inhibitory (n=2). Sixteen neurones responded at a threshold of 20 mmHg or less, five at 20-40 mmHg, and three at 40-80 mmHg. Three of 10 neurones tested showed increased responses to colonic distension after intraluminal perfusion with bile. Bile itself did not evoke a response. We conclude that lumbo-sacral spinal neurones selectively receive mechanosensory inputs from the distal colon. Neurones respond at thresholds within and above the physiological range. Dorsal horn neurones receiving colonic mechanosensory inputs are not directly modulated by chemosensory inputs, but their responsiveness to distension may be augmented.
Keywords: Lumbar Vertebrae; Colon; Spinal Cord; Neurons; Mechanoreceptors; Bile; Animals; Rats; Rats, Sprague-Dawley; Catheterization; Sensory Thresholds; Reaction Time; Electrophysiology; Neural Inhibition; Female; Chemoreceptor Cells
RMID: 0020011097
DOI: 10.1046/j.1365-2982.2001.00272.x
Appears in Collections:Physiology publications

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