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Type: Journal article
Title: Two new piperazine-triones from a marine-derived Streptomycetes sp. strain SMS636
Author: Han, J.
Lin, R.
Xu, X.
Polyak, S.W.
Song, F.
Citation: Marine Drugs, 2019; 17(3):186-1-186-7
Publisher: MDPI
Issue Date: 2019
ISSN: 1660-3397
Statement of
Xiuli Xu, Jiahui Han, Rui Lin, Steven W. Polyak and Fuhang Song
Abstract: Two new piperazine-triones lansai E and F (1, 2), together with four known secondary metabolites lansai D (3), 1-N-methyl-(E,Z)-albonoursin (4), imidazo[4,5-e]-1,2,4-triazine (5), and streptonigrin (6) were isolated from a deep-sea-derived Streptomycetes sp. strain SMS636. The structures of the isolated compounds were confirmed by comprehensive spectroscopic analysis, including HRESIMS, 1D and 2D NMR. Compound 4 exhibited moderate antibacterial activities against Staphylococcus aureus and methicillin resistant S. aureus (MRSA) with Minimum Inhibitory Concentration (MIC) values of 12.5 and 25 μg/mL, respectively. Compound 6 displayed significant antibacterial activities against S. aureus, MRSA and Bacillus Calmette-Guérin (BCG) with MIC values of 0.78, 0.78 and 1.25 μg/mL, respectively.
Keywords: Marine-derived Streptomycetes; piperazine-trione; antibacterial; MRSA
Rights: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
DOI: 10.3390/md17030186
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Molecular and Biomedical Science publications

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