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dc.contributor.authorHan, J.-
dc.contributor.authorLin, R.-
dc.contributor.authorXu, X.-
dc.contributor.authorPolyak, S.W.-
dc.contributor.authorSong, F.-
dc.identifier.citationMarine Drugs, 2019; 17(3):186-1-186-7-
dc.description.abstractTwo new piperazine-triones lansai E and F (1, 2), together with four known secondary metabolites lansai D (3), 1-N-methyl-(E,Z)-albonoursin (4), imidazo[4,5-e]-1,2,4-triazine (5), and streptonigrin (6) were isolated from a deep-sea-derived Streptomycetes sp. strain SMS636. The structures of the isolated compounds were confirmed by comprehensive spectroscopic analysis, including HRESIMS, 1D and 2D NMR. Compound 4 exhibited moderate antibacterial activities against Staphylococcus aureus and methicillin resistant S. aureus (MRSA) with Minimum Inhibitory Concentration (MIC) values of 12.5 and 25 μg/mL, respectively. Compound 6 displayed significant antibacterial activities against S. aureus, MRSA and Bacillus Calmette-Guérin (BCG) with MIC values of 0.78, 0.78 and 1.25 μg/mL, respectively.-
dc.description.statementofresponsibilityXiuli Xu, Jiahui Han, Rui Lin, Steven W. Polyak and Fuhang Song-
dc.rights© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
dc.subjectMarine-derived Streptomycetes; piperazine-trione; antibacterial; MRSA-
dc.titleTwo new piperazine-triones from a marine-derived Streptomycetes sp. strain SMS636-
dc.typeJournal article-
dc.identifier.orcidPolyak, S.W. [0000-0002-8458-5194]-
Appears in Collections:Aurora harvest 8
Molecular and Biomedical Science publications

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