Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/119836
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Type: | Journal article |
Title: | Two new piperazine-triones from a marine-derived Streptomycetes sp. strain SMS636 |
Author: | Han, J. Lin, R. Xu, X. Polyak, S.W. Song, F. |
Citation: | Marine Drugs, 2019; 17(3):186-1-186-7 |
Publisher: | MDPI |
Issue Date: | 2019 |
ISSN: | 1660-3397 1660-3397 |
Statement of Responsibility: | Xiuli Xu, Jiahui Han, Rui Lin, Steven W. Polyak and Fuhang Song |
Abstract: | Two new piperazine-triones lansai E and F (1, 2), together with four known secondary metabolites lansai D (3), 1-N-methyl-(E,Z)-albonoursin (4), imidazo[4,5-e]-1,2,4-triazine (5), and streptonigrin (6) were isolated from a deep-sea-derived Streptomycetes sp. strain SMS636. The structures of the isolated compounds were confirmed by comprehensive spectroscopic analysis, including HRESIMS, 1D and 2D NMR. Compound 4 exhibited moderate antibacterial activities against Staphylococcus aureus and methicillin resistant S. aureus (MRSA) with Minimum Inhibitory Concentration (MIC) values of 12.5 and 25 μg/mL, respectively. Compound 6 displayed significant antibacterial activities against S. aureus, MRSA and Bacillus Calmette-Guérin (BCG) with MIC values of 0.78, 0.78 and 1.25 μg/mL, respectively. |
Keywords: | Marine-derived Streptomycetes; piperazine-trione; antibacterial; MRSA |
Rights: | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
DOI: | 10.3390/md17030186 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1147538 |
Published version: | http://dx.doi.org/10.3390/md17030186 |
Appears in Collections: | Aurora harvest 8 Molecular and Biomedical Science publications |
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hdl_119836.pdf | Published Version | 469.87 kB | Adobe PDF | View/Open |
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