Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/119837
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dc.contributor.authorGonzález, J.en
dc.contributor.authorCáceres, A.en
dc.contributor.authorEsko, T.en
dc.contributor.authorCuscó, I.en
dc.contributor.authorPuig, M.en
dc.contributor.authorEsnaola, M.en
dc.contributor.authorReina, J.en
dc.contributor.authorSiroux, V.en
dc.contributor.authorBouzigon, E.en
dc.contributor.authorNadif, R.en
dc.contributor.authorReinmaa, E.en
dc.contributor.authorMilani, L.en
dc.contributor.authorBustamante, M.en
dc.contributor.authorJarvis, D.en
dc.contributor.authorAntó, J.en
dc.contributor.authorSunyer, J.en
dc.contributor.authorDemenais, F.en
dc.contributor.authorKogevinas, M.en
dc.contributor.authorMetspalu, A.en
dc.contributor.authorCáceres, M.en
dc.contributor.authoret al.en
dc.date.issued2014en
dc.identifier.citationAmerican Journal of Human Genetics, 2014; 94(3):361-372en
dc.identifier.issn0002-9297en
dc.identifier.issn1537-6605en
dc.identifier.urihttp://hdl.handle.net/2440/119837-
dc.description.abstractThe prevalence of asthma and obesity is increasing worldwide, and obesity is a well-documented risk factor for asthma. The mechanisms underlying this association and parallel time trends remain largely unknown but genetic factors may be involved. Here, we report on a common ~0.45 Mb genomic inversion at 16p11.2 that can be accurately genotyped via SNP array data. We show that the inversion allele protects against the joint occurrence of asthma and obesity in five large independent studies (combined sample size of 317 cases and 543 controls drawn from a total of 5,809 samples; combined OR = 0.48, p = 5.5 × 10(-6)). Allele frequencies show remarkable worldwide population stratification, ranging from 10% in East Africa to 49% in Northern Europe, consistent with discordant and extreme genetic drifts or adaptive selections after human migration out of Africa. Inversion alleles strongly correlate with expression levels of neighboring genes, especially TUFM (p = 3.0 × 10(-40)) that encodes a mitochondrial protein regulator of energy balance and inhibitor of type 1 interferon, and other candidates for asthma (IL27) and obesity (APOB48R and SH2B1). Therefore, by affecting gene expression, the ~0.45 Mb 16p11.2 inversion provides a genetic basis for the joint susceptibility to asthma and obesity, with a population attributable risk of 39.7%. Differential mitochondrial function and basal energy balance of inversion alleles might also underlie the potential selection signature that led to their uneven distribution in world populations.en
dc.description.statementofresponsibilityJuan R. Gonzalez, Alejandro Caceres, Tonu Esko, Ivon Cusco, Marta Puig ... Luis A. Perez-Jurado ... et al.en
dc.language.isoenen
dc.publisherCell Pressen
dc.rights© 2014 by The American Society of Human Genetics. All rights reserved.en
dc.subjectPolymorphism, Single Nucleotideen
dc.titleA common 16p11.2 inversion underlies the joint susceptibility to asthma and obesityen
dc.typeJournal articleen
dc.identifier.rmid0030079600en
dc.identifier.doi10.1016/j.ajhg.2014.01.015en
dc.identifier.pubid388543-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS10en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
Appears in Collections:Medicine publications

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