Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/119846
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dc.contributor.authorIacobucci, I.en
dc.contributor.authorWen, J.en
dc.contributor.authorMeggendorfer, M.en
dc.contributor.authorChoi, J.K.en
dc.contributor.authorShi, L.en
dc.contributor.authorPounds, S.B.en
dc.contributor.authorCarmichael, C.L.en
dc.contributor.authorMasih, K.E.en
dc.contributor.authorMorris, S.M.en
dc.contributor.authorLindsley, R.C.en
dc.contributor.authorJanke, L.J.en
dc.contributor.authorAlexander, T.B.en
dc.contributor.authorSong, G.en
dc.contributor.authorQu, C.en
dc.contributor.authorLi, Y.en
dc.contributor.authorPayne-Turner, D.en
dc.contributor.authorTomizawa, D.en
dc.contributor.authorKiyokawa, N.en
dc.contributor.authorValentine, M.en
dc.contributor.authorValentine, V.en
dc.contributor.authoret al.en
dc.date.issued2019en
dc.identifier.citationNature genetics, 2019; 51(4):694-704en
dc.identifier.issn1061-4036en
dc.identifier.issn1546-1718en
dc.identifier.urihttp://hdl.handle.net/2440/119846-
dc.description.abstractAcute erythroid leukemia (AEL) is a high-risk leukemia of poorly understood genetic basis, with controversy regarding diagnosis in the spectrum of myelodysplasia and myeloid leukemia. We compared genomic features of 159 childhood and adult AEL cases with non-AEL myeloid disorders and defined five age-related subgroups with distinct transcriptional profiles: adult, TP53 mutated; NPM1 mutated; KMT2A mutated/rearranged; adult, DDX41 mutated; and pediatric, NUP98 rearranged. Genomic features influenced outcome, with NPM1 mutations and HOXB9 overexpression being associated with a favorable prognosis and TP53, FLT3 or RB1 alterations associated with poor survival. Targetable signaling mutations were present in 45% of cases and included recurrent mutations of ALK and NTRK1, the latter of which drives erythroid leukemogenesis sensitive to TRK inhibition. This genomic landscape of AEL provides the framework for accurate diagnosis and risk stratification of this disease, and the rationale for testing targeted therapies in this high-risk leukemia.en
dc.description.statementofresponsibilityIlaria Iacobucci … L. Bik To, Ian D. Lewis, Richard J. D’Andrea … Anna L. Brown, Hamish S. Scott, Christopher H. Hahn … Charles G. Mullighanen
dc.language.isoenen
dc.publisherSpringer Natureen
dc.rightsCopyright © 2019, Springer Natureen
dc.subjectHumans; Leukemia, Erythroblastic, Acute; Homeodomain Proteins; Nuclear Proteins; Prognosis; Genomics; Mutation; Adolescent; Adult; Child; Child, Preschool; Infant; Infant, Newborn; Female; Male; Tumor Suppressor Protein p53; Myeloid-Lymphoid Leukemia Protein; fms-Like Tyrosine Kinase 3; Young Adulten
dc.titleGenomic subtyping and therapeutic targeting of acute erythroleukemiaen
dc.typeJournal articleen
dc.identifier.rmid0030112053en
dc.identifier.doi10.1038/s41588-019-0375-1en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/516726en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1016647en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1113577en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1063008en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/361646en
dc.identifier.pubid466149-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS14en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidKile, B.T. [0000-0002-8836-8947]en
dc.identifier.orcidBrown, A.L. [0000-0002-9023-0138]en
dc.identifier.orcidScott, H.S. [0000-0002-5813-631X]en
dc.identifier.orcidHahn, C.N. [0000-0001-5105-2554]en
dc.identifier.orcidMullighan, C.G. [0000-0002-1871-1850]en
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