Please use this identifier to cite or link to this item:
Scopus Web of ScienceĀ® Altmetric
Type: Journal article
Title: Is birthweight a good marker for gestational exposures that increase the risk of adult disease?
Author: Morley, R.
Owens, J.
Blair, E.
Dwyer, T.
Citation: Paediatric and Perinatal Epidemiology, 2002; 16(3):194-199
Publisher: Blackwell Science Ltd
Issue Date: 2002
ISSN: 0269-5022
Statement of
Ruth Morley, Julie Owens, Eve Blair and Terence Dwyer
Abstract: There is much evidence of a link between low birthweight and elevated risk of adult cardiovascular disease, from humans and experimental animals. However, if one relies on data linking birthweight to coronary heart disease to estimate the public health implications of this association, the effects are likely to be modest. The focus on birthweight may be misplaced, because reduced size at birth may not be in the causal pathway linking gestational factors to disease in adult offspring. We need to know more about this before we can estimate the public health implications of gestational factors and assess the potential for intervention. The most studied gestational factor is maternal nutrition. We review here evidence for and against birthweight being in the causal pathways between suboptimal maternal nutrition and increased risk of adult disease in the offspring and provide evidence suggesting that birthweight is not in all of them. From a public health point of view, we suggest that future research in this field should focus on modifiable gestational exposures that may be linked to adult disease, whether or not they influence size at birth.
Keywords: Animals; Humans; Fetal Growth Retardation; Coronary Disease; Starvation; Birth Weight; Risk Factors; Public Health; Maternal Exposure; Pregnancy; Adult; Australia; Female; Male; Biomarkers
Description: The definitive version is available at
RMID: 0020020544
DOI: 10.1046/j.1365-3016.2002.00428.x
Appears in Collections:Physiology publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.