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https://hdl.handle.net/2440/120026
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Type: | Journal article |
Title: | Association between microRNA-27a rs895819 polymorphism and risk of colorectal cancer: a meta-analysis |
Author: | Liu, F. Dear, K. Huang, L. Liu, L. Shi, Y. Nie, S. Liu, Y. Lu, Y. Xiang, H. |
Citation: | Cancer Genetics, 2016; 209(9):388-394 |
Publisher: | Elsevier |
Issue Date: | 2016 |
ISSN: | 2210-7762 2210-7770 |
Statement of Responsibility: | Feifei Liu, Keith Dear, Lei Huang, Li Liu, Yun Shi, Shaofa Nie, Yisi Liua, Yuanan Luf, Hao Xiang |
Abstract: | Colorectal cancer (CRC) is the most common malignancy in the human digestive system. Previous results regarding the association between microRNA-27a rs895819 polymorphisms and CRC risk are controversial. We therefore performed a meta-analysis of seven studies totaling 2230 cases and 2775 controls to systematically evaluate this association. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were obtained using a fixed-effects model. A moderate evidence for the association between mir-27a polymorphism and CRC risk was found under multiple genetic models (dominant model: OR = 1.15, 95% CI: 1.02-1.29, p = 0.02; recessive model: OR = 1.49, 95% CI: 1.27-1.76, p <0.001; homozygote model: OR = 1.53, 95% CI: 1.28-1.83, p <0.001; allele model: OR = 1.21, 95% CI: 1.11-1.31, p <0.001). Subgroup analysis showed a significant association between mir-27a rs895819 polymorphism and CRC risk among Chinese populations. On the contrary, we found no evidence of association among Caucasian populations due to small samples (p > 0.05). In conclusion, this meta-analysis suggested that rs895819 polymorphism in mir-27a may be a potential genetic risk factor for CRC, particularly in Chinese populations. |
Keywords: | Mir-27a; colorectal cancer; polymorphism; meta-analysis |
Rights: | © 2016 Elsevier Inc. All rights reserved. |
DOI: | 10.1016/j.cancergen.2016.08.003 |
Published version: | http://dx.doi.org/10.1016/j.cancergen.2016.08.003 |
Appears in Collections: | Aurora harvest 4 Public Health publications |
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