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Type: Journal article
Title: Repolarization variability independent of heart rate during sympathetic activation elicited by head-up tilt
Author: El-hamad, F.
Javorka, M.
Czippelova, B.
Krohova, J.
Turianikova, Z.
Porta, A.
Baumert, M.
Citation: Medical and Biological Engineering and Computing, 2019; 57(8):1753-1762
Publisher: Springer Verlag
Issue Date: 2019
ISSN: 0140-0118
Statement of
Fatima El-Hamad, Michal Javorka, Barbora Czippelova, Jana Krohova, Zuzana Turianikova, Alberto Porta, Mathias Baumert
Abstract: The fraction of repolarization variability independent of RR interval variability is of clinical interest. It has been linked to direct autonomic nervous system (ANS) regulation of the ventricles in healthy subjects and seems to reflect the instability of the ventricular repolarization process in heart disease. In this study, we sought to identify repolarization measures that best reflect the sympathetic influences on the ventricles independent of the RR interval. ECG was recorded in 46 young subjects during supine and then following 45 degrees head-up tilt. RR intervals and five repolarization features (QTend, QTpeak, RTend, RTpeak, and TpTe) were extracted from the ECG recordings. Repolarization variability was separated into RR-dependent and RR-independent variability using parametric spectral analysis. Results show that LF power of TpTe is independent of RR in both supine and tilt, while the LF power of QTend and RTend independent of RR and respiration increases following tilt. We conclude that TpTe is independent of RR and is highly affected by respiration. QTend and RTend LF power might reflect the sympathetic influences on the ventricles elicited by tilt. Graphical abstract.
Keywords: Autonomic nervous system
Head-up tilt
Heart rate variability
QT interval
Sympathetic activation
Rights: © International Federation for Medical and Biological Engineering 2019
DOI: 10.1007/s11517-019-01998-9
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Electrical and Electronic Engineering publications

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