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Type: Journal article
Title: Emu Oil reduces disease severity in a mouse model of chronic ulcerative colitis
Author: Safaeian, R.
Howarth, G.S.
Lawrance, I.C.
Trinder, D.
Mashtoub, S.
Citation: Scandinavian Journal of Gastroenterology, 2019; 31(3):273-280
Publisher: Taylor & Francis
Issue Date: 2019
ISSN: 0036-5521
Statement of
Romina Safaeian, Gordon S. Howarth, Ian C. Lawrance, Debbie Trinder and Suzanne Mashtoub
Abstract: OBJECTIVE:Ulcerative colitis (UC) is characterized by mucosal inflammation and ulceration of the large intestine. Emu Oil (EO) has been reported to protect the intestine against mucositis, NSAID-enteropathy, UC-associated colorectal cancer and acute UC. We aimed to determine whether EO could reduce the severity chronic UC in mice. METHODS:Female C57BL/6 mice (n = 10/group) were orally administered (gavage) water (Groups 1-2) or EO (Groups 3: low dose-80 µl and 4: high dose-160 µl), thrice weekly. Group 1 mice consumed plain drinking water throughout the trial. Groups 2-4 mice underwent two cycles [each consisting of seven days dextran sulfate sodium (DSS; 2% w/v) and 14 days water], followed by a third DSS week. All mice were euthanized two days later (day 51). Bodyweight, disease activity index (DAI), burrowing activity, myeloperoxidase activity, crypt depth and histologically assessed damage severity were assessed. p < .05 was considered significant. RESULTS:DSS decreased bodyweight and increased DAI compared to normal controls (p < .05), which was partially attenuated by both EO doses (p < .05). Burrowing activity was impaired in DSS-controls compared to normal controls (days 27 and 40); an effect prevented by both EO doses (p < .05). DSS increased colonic myeloperoxidase activity and crypt depth compared to controls (p < .05), with no significant EO effect. Moreover, DSS increased colonic damage severity compared to normal controls (p < .001). Importantly, both EO doses decreased distal colonic damage severity compared to DSS-controls (p < .001). CONCLUSIONS:Emu Oil attenuated clinically- and histologically-assessed disease severity in a mouse model of chronic UC. Emu Oil demonstrates promise as an adjunct to conventional treatment options for UC management.
Keywords: Emu Oil; Ulcerative colitis; chronic; inflammatory bowel disease; mice
Rights: © 2019 Informa UK Limited, trading as Taylor & Francis Group
RMID: 0030076030
DOI: 10.1080/00365521.2019.1581253
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Appears in Collections:Medicine publications

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