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https://hdl.handle.net/2440/120178
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dc.contributor.author | Safaeian, R. | - |
dc.contributor.author | Howarth, G.S. | - |
dc.contributor.author | Lawrance, I.C. | - |
dc.contributor.author | Trinder, D. | - |
dc.contributor.author | Mashtoub, S. | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Scandinavian Journal of Gastroenterology, 2019; 31(3):273-280 | - |
dc.identifier.issn | 0036-5521 | - |
dc.identifier.issn | 1502-7708 | - |
dc.identifier.uri | http://hdl.handle.net/2440/120178 | - |
dc.description.abstract | OBJECTIVE:Ulcerative colitis (UC) is characterized by mucosal inflammation and ulceration of the large intestine. Emu Oil (EO) has been reported to protect the intestine against mucositis, NSAID-enteropathy, UC-associated colorectal cancer and acute UC. We aimed to determine whether EO could reduce the severity chronic UC in mice. METHODS:Female C57BL/6 mice (n = 10/group) were orally administered (gavage) water (Groups 1-2) or EO (Groups 3: low dose-80 µl and 4: high dose-160 µl), thrice weekly. Group 1 mice consumed plain drinking water throughout the trial. Groups 2-4 mice underwent two cycles [each consisting of seven days dextran sulfate sodium (DSS; 2% w/v) and 14 days water], followed by a third DSS week. All mice were euthanized two days later (day 51). Bodyweight, disease activity index (DAI), burrowing activity, myeloperoxidase activity, crypt depth and histologically assessed damage severity were assessed. p < .05 was considered significant. RESULTS:DSS decreased bodyweight and increased DAI compared to normal controls (p < .05), which was partially attenuated by both EO doses (p < .05). Burrowing activity was impaired in DSS-controls compared to normal controls (days 27 and 40); an effect prevented by both EO doses (p < .05). DSS increased colonic myeloperoxidase activity and crypt depth compared to controls (p < .05), with no significant EO effect. Moreover, DSS increased colonic damage severity compared to normal controls (p < .001). Importantly, both EO doses decreased distal colonic damage severity compared to DSS-controls (p < .001). CONCLUSIONS:Emu Oil attenuated clinically- and histologically-assessed disease severity in a mouse model of chronic UC. Emu Oil demonstrates promise as an adjunct to conventional treatment options for UC management. | - |
dc.description.statementofresponsibility | Romina Safaeian, Gordon S. Howarth, Ian C. Lawrance, Debbie Trinder and Suzanne Mashtoub | - |
dc.language.iso | en | - |
dc.publisher | Taylor & Francis | - |
dc.rights | © 2019 Informa UK Limited, trading as Taylor & Francis Group | - |
dc.source.uri | http://dx.doi.org/10.1080/00365521.2019.1581253 | - |
dc.subject | Emu Oil | - |
dc.subject | Ulcerative colitis | - |
dc.subject | chronic | - |
dc.subject | inflammatory bowel disease | - |
dc.subject | mice | - |
dc.title | Emu Oil reduces disease severity in a mouse model of chronic ulcerative colitis | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1080/00365521.2019.1581253 | - |
dc.relation.grant | NHMRC | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1020437 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Safaeian, R. [0000-0001-7559-936X] | - |
dc.identifier.orcid | Howarth, G.S. [0000-0001-6979-6084] | - |
dc.identifier.orcid | Mashtoub, S. [0000-0001-7308-8371] | - |
Appears in Collections: | Aurora harvest 8 Medicine publications |
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