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Type: Journal article
Title: Adipose-derived stem cells for wound healing
Author: Hassanshahi, A.
Hassanshahi, M.
Khabbazi, S.
Hosseini-Khah, Z.
Peymanfar, Y.
Ghalamkari, S.
Su, Y.W.
Xian, C.J.
Citation: Journal of Cellular Physiology, 2019; 234(6):7903-7914
Publisher: Wiley Online Library
Issue Date: 2019
ISSN: 0021-9541
Statement of
Alireza Hassanshahi, Mohammadhossein Hassanshahi, Samira Khabbazi, Zahra Hosseini‐Khah, Yaser Peymanfar, Saman Ghalamkari, Yu‐Wen Su, Cory J. Xian
Abstract: Wound healing is a complex but a fine-tuned biological process in which human skin has the ability to regenerate itself following damage. However, in particular conditions such as deep burn or diabetes the process of wound healing is compromised. Despite investigations on the potency of a wide variety of stem cells for wound healing, adipose-derived stem cells (ASCs) seem to possess the least limitations for clinical applications, and literature showed that ASCs can improve the process of wound healing very likely by promoting angiogenesis and/or vascularisation, modulating immune response, and inducing epithelialization in the wound. In the present review, advantages and disadvantages of various stem cells which can be used for promoting wound healing are discussed. In addition, potential mechanisms of action by which ASCs may accelerate wound healing are summarised. Finally, clinical studies applying ASCs for wound healing and the associated limitations are reviewed.
Keywords: adipose-derived stem cells; angiogenesis; mesenchymal stem cells; stem cells; stromal vascular fraction; wound healing
Rights: © 2018 Wiley Periodicals, Inc.
RMID: 0030105748
DOI: 10.1002/jcp.27922
Grant ID:
Appears in Collections:Medicine publications

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