Please use this identifier to cite or link to this item:
Full metadata record
|dc.contributor.author||De Courten, M.||en|
|dc.contributor.author||De Courten, B.||en|
|dc.identifier.citation||Minerva Endocrinologica, 2015; 40(3):213-230||en|
|dc.description.abstract||Obesity, type 2 diabetes, and cardiovascular disease (CVD) are the most common preventable causes of morbidity and mortality worldwide. Insulin resistance, which is a shared feature in these conditions, is also strongly linked to the development of polycystic ovary syndrome (PCOS), which is the most common endocrine disease in women of reproductive age and a major cause of infertility. Vitamin D deficiency has reached epidemic proportions worldwide, primarily due to the shift to sedentary, indoor lifestyles and sun avoidance behaviours to protect against skin cancer. In recent years, vitamin D deficiency has been implicated in the aetiology of type 2 diabetes, PCOS and CVD, and has been shown to be associated with their risk factors including obesity, insulin resistance, hypertension, as well as chronic low-grade inflammation. Treating vitamin D deficiency may offer a feasible and cost-effective means of reducing cardiometabolic risk factors at a population level in order to prevent the development of type 2 diabetes and CVD. However, not all intervention studies show that vitamin D supplementation alleviates these risk factors. Importantly, there is significant heterogeneity in existing studies with regards to doses and drug regimens used, populations studied (i.e. vitamin D deficient or sufficient), and the lengths of supplementation, and only few studies have directly examined the effect of vitamin D on insulin secretion and resistance with the use of clamp methods. Therefore, there is a need for well-designed large scale trials to clarify the role of vitamin D supplementation in the prevention of type 2 diabetes, PCOS, and CVD.||en|
|dc.description.statementofresponsibility||A. Mousa, N. Naderpoor, H.J. Teede, M.P.J. De Courten, R. Scragg, B. De Courten||en|
|dc.publisher||Edizioni Minerva Medica||en|
|dc.rights||Copyright Status Unknown||en|
|dc.subject||Vitamin D; obesity; insulin resistance; polycystic ovary syndrome; inflammation cardiovascular diseases; diabetes mellitus||en|
|dc.title||Vitamin D and cardiometabolic risk factors and diseases||en|
|Appears in Collections:||Medicine publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.