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https://hdl.handle.net/2440/120216
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DC Field | Value | Language |
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dc.contributor.author | Mousa, A. | - |
dc.contributor.author | Naderpoor, N. | - |
dc.contributor.author | Teede, H.J. | - |
dc.contributor.author | De Courten, M.P.J. | - |
dc.contributor.author | Scragg, R. | - |
dc.contributor.author | De Courten, B. | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Minerva Endocrinologica: a journal on endocrine system diseases, 2015; 40(3):213-230 | - |
dc.identifier.issn | 0391-1977 | - |
dc.identifier.issn | 1827-1634 | - |
dc.identifier.uri | http://hdl.handle.net/2440/120216 | - |
dc.description.abstract | Obesity, type 2 diabetes, and cardiovascular disease (CVD) are the most common preventable causes of morbidity and mortality worldwide. Insulin resistance, which is a shared feature in these conditions, is also strongly linked to the development of polycystic ovary syndrome (PCOS), which is the most common endocrine disease in women of reproductive age and a major cause of infertility. Vitamin D deficiency has reached epidemic proportions worldwide, primarily due to the shift to sedentary, indoor lifestyles and sun avoidance behaviours to protect against skin cancer. In recent years, vitamin D deficiency has been implicated in the aetiology of type 2 diabetes, PCOS and CVD, and has been shown to be associated with their risk factors including obesity, insulin resistance, hypertension, as well as chronic low-grade inflammation. Treating vitamin D deficiency may offer a feasible and cost-effective means of reducing cardiometabolic risk factors at a population level in order to prevent the development of type 2 diabetes and CVD. However, not all intervention studies show that vitamin D supplementation alleviates these risk factors. Importantly, there is significant heterogeneity in existing studies with regards to doses and drug regimens used, populations studied (i.e. vitamin D deficient or sufficient), and the lengths of supplementation, and only few studies have directly examined the effect of vitamin D on insulin secretion and resistance with the use of clamp methods. Therefore, there is a need for well-designed large scale trials to clarify the role of vitamin D supplementation in the prevention of type 2 diabetes, PCOS, and CVD. | - |
dc.description.statementofresponsibility | A. Mousa, N. Naderpoor, H.J. Teede, M.P.J. De Courten, R. Scragg, B. De Courten | - |
dc.language.iso | en | - |
dc.publisher | Edizioni Minerva Medica | - |
dc.rights | Copyright Status Unknown | - |
dc.subject | Vitamin D; obesity; insulin resistance; polycystic ovary syndrome; inflammation cardiovascular diseases; diabetes mellitus | - |
dc.title | Vitamin D and cardiometabolic risk factors and diseases | - |
dc.type | Journal article | - |
dc.relation.grant | NHMRC | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Teede, H.J. [0000-0001-7609-577X] | - |
Appears in Collections: | Aurora harvest 8 Medicine publications |
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