Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/120438
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Type: Journal article
Title: Impact of different intensities of intermittent theta burst stimulation on the cortical properties during TMS-EEG and working memory performance
Author: Chung, S.
Rogasch, N.
Hoy, K.
Sullivan, C.
Cash, R.
Fitzgerald, P.
Citation: Human Brain Mapping, 2018; 39(2):783-802
Publisher: Wiley
Issue Date: 2018
ISSN: 1065-9471
1097-0193
Statement of
Responsibility: 
Sung Wook Chung, Nigel C. Rogasch, Kate E. Hoy, Caley M. Sullivan, Robin F.H. Cash, Paul B. Fitzgerald
Abstract: Intermittent theta burst stimulation (iTBS) is a noninvasive brain stimulation technique capable of increasing cortical excitability beyond the stimulation period. Due to the rapid induction of modulatory effects, prefrontal application of iTBS is gaining popularity as a therapeutic tool for psychiatric disorders such as depression. In an attempt to increase efficacy, higher than conventional intensities are currently being applied. The assumption that this increases neuromodulatory may be mechanistically false for iTBS. This study examined the influence of intensity on the neurophysiological and behavioural effects of iTBS in the prefrontal cortex. Sixteen healthy participants received iTBS over prefrontal cortex at either 50, 75 or 100% resting motor threshold in separate sessions. Single-pulse TMS and concurrent electroencephalography (EEG) was used to assess changes in cortical reactivity measured as TMS-evoked potentials and oscillations. The n-back task was used to assess changes in working memory performance. The data can be summarised as an inverse U-shape relationship between intensity and iTBS plastic effects, where 75% iTBS yielded the largest neurophysiological changes. Improvement in reaction time in the 3-back task was supported by the change in alpha power, however, comparison between conditions revealed no significant differences. The assumption that higher intensity results in greater neuromodulatory effects may be false, at least in healthy individuals, and should be carefully considered for clinical populations. Neurophysiological changes associated with working memory following iTBS suggest functional relevance. However, the effects of different intensities on behavioural performance remain elusive in the present healthy sample.
Keywords: Intensity; prefrontal cortex; theta burst stimulation (TBS); TMS-EEG; working memory
Rights: © 2017 Wiley Periodicals, Inc.
RMID: 0030120393
DOI: 10.1002/hbm.23882
Grant ID: http://purl.org/au-research/grants/nhmrc/1072057
http://purl.org/au-research/grants/nhmrc/1082894
http://purl.org/au-research/grants/nhmrc/1078567
Appears in Collections:Medicine publications

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